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Gene Review:

Rnaset2b - ribonuclease T2B

Mus musculus

Synonyms: 0610007O07Rik, 4833423A10Rik, 4930532K22Rik, C79750, RNASE6PL, ...

Acquati, F. et al.

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Disease relevance of Rnaset2b

We therefore propose that RNASE6PL may be a candidate for the 6q27 senescence inducing and class II tumor suppressor gene in ovarian cancer [1].
Moreover, 63.6% of HEY4 clones and 42.8% of the clones of XP12ROSV, a Xeroderma pigmentosum SV40-immortalized cell line, transfected with RNASE6PL cDNA, developed a marked senescence process during in vitro growth [1].

High impact information on Rnaset2b

Analysis of 55 primary ovarian tumors and several ovarian tumor cell lines indicated that the RNASE6PL gene is not mutated in tumor tissues, but its expression is significantly reduced in 30% of primary ovarian tumors and in 75% of ovarian tumor cell lines [1].

Biological context of Rnaset2b

Transfection of RNASE6PL cDNA into HEY4 and SG10G ovarian tumor cell lines suppressed tumorigenicity in nude mice [1].

References

Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Acquati, F., Morelli, C., Cinquetti, R., Bianchi, M.G., Porrini, D., Varesco, L., Gismondi, V., Rocchetti, R., Talevi, S., Possati, L., Magnanini, C., Tibiletti, M.G., Bernasconi, B., Daidone, M.G., Shridhar, V., Smith, D.I., Negrini, M., Barbanti-Brodano, G., Taramelli, R. Oncogene (2001) [Pubmed]

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