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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SUPT6H  -  suppressor of Ty 6 homolog (S. cerevisiae)

Homo sapiens

Synonyms: Histone chaperone suppressor of Ty6, KIAA0162, SPT6, SPT6H, Tat-CT2 protein, ...
 
 
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Disease relevance of SUPT6H

  • However, HIV-1 and c-myc RNAs formed in cells expressing the mutant Spt6 protein were longer than normal and contained splicing defects [1].
 

High impact information on SUPT6H

  • Surprisingly, a point mutation in the Spt6 SH2 domain (R1358K) blocked binding to RNAPIIo without affecting transcription elongation rates in vitro [1].
  • We show here that mammalian Spt6 binds Ser2-phosphorylated (Ser2P) RNA polymerase II (RNAPII) through a primitive SH2 domain, which recognizes phosphoserine rather than phosphotyrosine residues [1].
  • From centromere to telomere, the approximately 0.8-Mb SRO includes sequence-tagged site 64381, the SUPT6H gene (encoding a transcription factor involved in chromatin structure), and NF1 [2].
  • This allows the deduction of a model by which pUL69 acts as an antirepressor by competing for binding of histones to hSPT6, thereby antagonizing the chromatin remodeling function of this cellular protein [3].
  • This correlated with a loss of the transactivation potential of the respective mutants, suggesting that the hSPT6 interaction of pUL69 is essential for stimulating gene expression [3].
 

Other interactions of SUPT6H

  • The Spt4, Spt5, and Spt6 proteins are conserved eukaryotic transcription-elongation factors [4].

References

  1. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Yoh, S.M., Cho, H., Pickle, L., Evans, R.M., Jones, K.A. Genes Dev. (2007) [Pubmed]
  2. NF1 microdeletion syndrome: refined FISH characterization of sporadic and familial deletions with locus-specific probes. Riva, P., Corrado, L., Natacci, F., Castorina, P., Wu, B.L., Schneider, G.H., Clementi, M., Tenconi, R., Korf, B.R., Larizza, L. Am. J. Hum. Genet. (2000) [Pubmed]
  3. Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6. Winkler, M., aus Dem Siepen, T., Stamminger, T. J. Virol. (2000) [Pubmed]
  4. Control of eukaryotic transcription elongation. Winston, F. Genome Biol. (2001) [Pubmed]
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