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Gene Review

Crip2  -  cysteine rich protein 2

Mus musculus

Synonyms: 0610010I23Rik, AW743261, C77570, CRP-2, CRP2, ...
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Disease relevance of Crip2

  • In order to identify transcriptional regulators involved in virulence gene control in Brucella melitensis, we generated a collection of 88 mutants in the AraC, ArsR, Crp, DeoR, GntR, IclR, LysR, MerR, RpiR, and TetR families of regulators [1].

High impact information on Crip2


Anatomical context of Crip2

  • In addition to expression in vascular smooth muscle cells, we also detect CRP2-specific transcripts in mesenchymal derivatives and several epithelia [4].

Analytical, diagnostic and therapeutic context of Crip2


  1. Systematic targeted mutagenesis of Brucella melitensis 16M reveals a major role for GntR regulators in the control of virulence. Haine, V., Sinon, A., Van Steen, F., Rousseau, S., Dozot, M., Lestrate, P., Lambert, C., Letesson, J.J., De Bolle, X. Infect. Immun. (2005) [Pubmed]
  2. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. Shirafuji, Y., Tanabe, H., Satchell, D.P., Henschen-Edman, A., Wilson, C.L., Ouellette, A.J. J. Biol. Chem. (2003) [Pubmed]
  3. The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family. Yu, T.S., Moctezuma-Anaya, M., Kubo, A., Keller, G., Robertson, S. Mech. Dev. (2002) [Pubmed]
  4. Expression of the gene encoding the LIM protein CRP2: a developmental profile. Henderson, J.R., Brown, D., Richardson, J.A., Olson, E.N., Beckerle, M.C. J. Histochem. Cytochem. (2002) [Pubmed]
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