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Gene Review

Crip2  -  cysteine-rich protein 2

Rattus norvegicus

Synonyms: CRP-2, Crp2, Cysteine-rich protein 2, Protein ESP1
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High impact information on Crip2


Biological context of Crip2

  • The ubiquitous tissue distribution and high level of expression of CRP2 mRNA suggest an important role for CRP2 in cell functions [3].
  • It encodes a protein, denoted cysteine-rich protein 2 (CRP2), of 208 amino acid residues containing two tandem repeats of an unusual LIM/double zinc-finger-like motif [3].

Anatomical context of Crip2

  • Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle [1].

Analytical, diagnostic and therapeutic context of Crip2

  • Among the changes observed following array analysis, increased nerve-growth-factor-induced B (NGFI-B), adenylyl cyclase type VIII (AC VIII), and reduced cysteine-rich protein 2 (CRP2) mRNA were confirmed by quantitative RT-PCR [4].


  1. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. Huber, A., Neuhuber, W.L., Klugbauer, N., Ruth, P., Allescher, H.D. J. Biol. Chem. (2000) [Pubmed]
  2. An effect of androgens on the length of the poly(A)-tail and alternative splicing cause size heterogeneity of the messenger ribonucleic acids encoding cystatin-related protein. Vercaeren, I., Winderickx, J., Devos, A., Peeters, B., Heyns, W. Endocrinology (1993) [Pubmed]
  3. Cloning of CRP2, a novel member of the cysteine-rich protein family with two repeats of an unusual LIM/double zinc-finger motif. Okano, I., Yamamoto, T., Kaji, A., Kimura, T., Mizuno, K., Nakamura, T. FEBS Lett. (1993) [Pubmed]
  4. Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Freeman, W.M., Brebner, K., Patel, K.M., Lynch, W.J., Roberts, D.C., Vrana, K.E. Neurochem. Res. (2002) [Pubmed]
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