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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TM4SF4  -  transmembrane 4 L six family member 4

Homo sapiens

Synonyms: IL-TMP, ILTMP, Intestine and liver tetraspan membrane protein, Transmembrane 4 L6 family member 4, il-TMP
 
 
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Disease relevance of TM4SF4

 

High impact information on TM4SF4

  • (i) Accumulation of il-TMP glycoforms precedes terminal differentiation of HT-29-inosine cells and occurs as they undergo density-dependent cessation of growth. il-TMP levels are lower and glycosylation less extensive in HT-29-glucose cells, which do not undergo growth arrest at confluence [1].
  • (ii) HeLa cells normally do not produce il-TMP [1].
  • L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains [2].
  • The remaining antigens, A15, CoO29, KRAG, L6, TI-1 and il-TMP, are expressed at low levels in very few cell lines without any specific pattern [3].
  • It was supposed that rat TM4SF4 might play a role in cell proliferation and in liver regeneration [4].
 

Biological context of TM4SF4

  • The extent of il-TMP glycosylation in the transfected cells is similar to that observed in HT-29-inosine cells and greater than in HT-29-glucose cells [1].
 

Analytical, diagnostic and therapeutic context of TM4SF4

References

  1. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. Wice, B.M., Gordon, J.I. J. Biol. Chem. (1995) [Pubmed]
  2. The L6 membrane proteins--a new four-transmembrane superfamily. Wright, M.D., Ni, J., Rudy, G.B. Protein Sci. (2000) [Pubmed]
  3. Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines. Ferrer, M., Yunta, M., Lazo, P.A. Clin. Exp. Immunol. (1998) [Pubmed]
  4. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1). Liu, Z., Zhao, M., Yokoyama, K.K., Li, T. Biochim. Biophys. Acta (2001) [Pubmed]
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