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Gene Review

TSPAN7  -  tetraspanin 7

Homo sapiens

Synonyms: A15, CCG-B7, CD231, Cell surface glycoprotein A15, DXS1692E, ...
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Disease relevance of TSPAN7


Psychiatry related information on TSPAN7

  • Dopamine (DA) is produced in numerous brain areas and influences a wide variety of social behaviors, but very few data are available to establish the socially-relevant response properties of most DA populations, which comprise eight cell groups numbered A8-A15 [5].

High impact information on TSPAN7


Chemical compound and disease context of TSPAN7

  • The highly conserved A15-G16 dipeptide may play a role in the function of fusion domain of HIV-1 envelope glycoprotein [7].

Biological context of TSPAN7

  • The cDNA was also essentially identical to A15, which was isolated from another T-ALL cell line, HPB-ALL, by differential hybridization with normal peripheral blood lymphocytes, and to CCG-B7, which was isolated from a brain cDNA library using CCG repeat as a probe [2].
  • The A15 gene codes for a protein of 244 amino acids which contains four potential transmembrane domains and four possible N-linked glycosylation sites [8].
  • Our findings provide a novel insight into the malignant phenotype of DSRCT, suggesting that TALLA-1 is a useful marker for diagnosis and a potential target for the therapy of DSRCT [9].
  • The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation [10].
  • A cosmid library has been constructed with DNA isolated from a mouse/human hybrid cell line designated A15, which was previously characterized and shown to retain chromosome 15 as the only human material [11].

Anatomical context of TSPAN7

  • The A15 is expressed in immature human T cells and in the human brain [1].
  • Total FMLP-ase and carboxypeptidase activities were similar in controls and UC patients but were substantially reduced in CD, especially in the terminal ileum (controls 493 +/- 146 and 116 +/- 73 nmol/100 micrograms protein per h, respectively and CD 231 +/- 96 and 41 +/- 36 nmol/100 micrograms protein per h, respectively (P = 0.0018 and 0.015) [12].
  • A15-year-old girl who developed traumatic iliacus hematoma and complete paralysis of the quadriceps muscle is reported [13].

Associations of TSPAN7 with chemical compounds

  • The primary structure of the peptide was established as: [formula: see text] This amino acid sequence contains several unusual substitutions (Gln-->Lys at A5, His-->Leu at A8, Gln-->Glu at A15, and Gly -->Ala at B20) that are not present in other amphibian insulins [14].
  • To clarify whether this molecule belongs to hsc73 itself, the membrane protein fraction of Daudi cells was isolated by Triton X-114 phase separation and the reactivity of this membrane protein fraction was assessed with monoclonal antibodies (mAbs) which react with 70 kDa heat shock protein (hsp) family, i.e., NT22, A15 and 3A3 [15].
  • Similar observations were made when the pair of cysteines (A10-A15) was replaced by either alanine or serine, whereby serine disturbs more than alanine [16].

Other interactions of TSPAN7


Analytical, diagnostic and therapeutic context of TSPAN7


  1. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. Virtaneva, K.I., Emi, N., Marken, J.S., Aruffo, A., Jones, C., Spurr, N.K., Schröder, J.P. Immunogenetics (1994) [Pubmed]
  2. Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. Takagi, S., Fujikawa, K., Imai, T., Fukuhara, N., Fukudome, K., Minegishi, M., Tsuchiya, S., Konno, T., Hinuma, Y., Yoshie, O. Int. J. Cancer (1995) [Pubmed]
  3. Does the P172H mutation at the TM4SF2 gene cause X-linked mental retardation? Maranduba, C.M., Sá Moreira, E., Müller Orabona, G., Pavanello, R.C., Vianna-Morgante, A.M., Passos-Bueno, M.R. Am. J. Med. Genet. A (2004) [Pubmed]
  4. Molecular nature of a cell membrane antigen specific for human T-cell acute lymphoblastic leukemia. Matsuzaki, H., Seon, B.K. Cancer Res. (1987) [Pubmed]
  5. Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches. Bharati, I.S., Goodson, J.L. Neuroscience (2006) [Pubmed]
  6. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Zemni, R., Bienvenu, T., Vinet, M.C., Sefiani, A., Carrié, A., Billuart, P., McDonell, N., Couvert, P., Francis, F., Chafey, P., Fauchereau, F., Friocourt, G., des Portes, V., Cardona, A., Frints, S., Meindl, A., Brandau, O., Ronce, N., Moraine, C., van Bokhoven, H., Ropers, H.H., Sudbrak, R., Kahn, A., Fryns, J.P., Beldjord, C., Chelly, J. Nat. Genet. (2000) [Pubmed]
  7. The amino-terminal fusion domain peptide of human immunodeficiency virus type 1 gp41 inserts into the sodium dodecyl sulfate micelle primarily as a helix with a conserved glycine at the micelle-water interface. Chang, D.K., Cheng, S.F., Chien, W.J. J. Virol. (1997) [Pubmed]
  8. Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily. Emi, N., Kitaori, K., Seto, M., Ueda, R., Saito, H., Takahashi, T. Immunogenetics (1993) [Pubmed]
  9. A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor. Ito, E., Honma, R., Imai, J., Azuma, S., Kanno, T., Mori, S., Yoshie, O., Nishio, J., Iwasaki, H., Yoshida, K., Gohda, J., Inoue, J., Watanabe, S., Semba, K. Am. J. Pathol. (2003) [Pubmed]
  10. The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. Wolf, R., Voscopoulos, C.J., FitzGerald, P.C., Goldsmith, P., Cataisson, C., Gunsior, M., Walz, M., Ruzicka, T., Yuspa, S.H. J. Invest. Dermatol. (2006) [Pubmed]
  11. Construction and screening of a cosmid library generated from a somatic cell hybrid bearing human chromosome 15. McDaniel, L.D., Zhang, B., Kubiczek, E., Ritter, M., Huang, J., Berard, C., Leana-Cox, J., Schwartz, S., Schultz, R.A. Genomics (1997) [Pubmed]
  12. Enzymes degrading bacterial chemotactic F-met peptides in human ileal and colonic mucosa. Chadwick, V.S., Schlup, M.M., Cooper, B.T., Broom, M.F. J. Gastroenterol. Hepatol. (1990) [Pubmed]
  13. Complete paralysis of the quadriceps muscle caused by traumatic iliacus hematoma: a case report. Tamai, K., Kuramochi, T., Sakai, H., Iwami, N., Saotome, K. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2002) [Pubmed]
  14. Purification and structural characterization of insulin from a caecilian, Typhlonectes natans (Amphibia: Gymnophiona). Conlon, J.M., Hilscher-Conklin, C., Boyd, S.K. Peptides (1995) [Pubmed]
  15. Localization of pNT22 70 kDa heat shock cognate-like protein in the plasma membrane. Hirai, I., Sato, N., Qi, W., Ohtani, S., Torigoe, T., Kikuchi, K. Cell Struct. Funct. (1998) [Pubmed]
  16. Structural contribution of the A-chain loop in relaxin. Büllesbach, E.E., Schwabe, C. Int. J. Pept. Protein Res. (1995) [Pubmed]
  17. A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58. Abidi, F.E., Holinski-Feder, E., Rittinger, O., Kooy, F., Lubs, H.A., Stevenson, R.E., Schwartz, C.E. J. Med. Genet. (2002) [Pubmed]
  18. Family MRX9 revisited: further evidence for locus heterogeneity in MRX. Winnepenninckx, B., Errijgers, V., Reyniers, E., De Deyn, P.P., Abidi, F.E., Schwartz, C.E., Kooy, R.F. Am. J. Med. Genet. (2002) [Pubmed]
  19. Identification of peptides in antimicrobial fractions of cheese extracts by electrospray ionization ion trap mass spectrometry coupled to a two-dimensional liquid chromatographic separation. Losito, I., Carbonara, T., Domenica De Bari, M., Gobbetti, M., Palmisano, F., Rizzello, C.G., Zambonin, P.G. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
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