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Gene Review

Kif23  -  kinesin family member 23

Mus musculus

Synonyms: 3110001D19Rik, C87313, CHO1, Kinesin-like protein KIF23, Knsl5, ...
 
 
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Psychiatry related information on Kif23

  • In Caenorhabditis elegans, in which cholinergic signaling supports motor activity and mutant alleles impacting ACh secretion and response can be propagated, we investigated the contribution of CHT (CHO-1) to facets of cholinergic neurobiology [1].
 

High impact information on Kif23

  • Surprisingly, the sequence encoded by exon 18 possesses a capability to interact with F-actin, suggesting that CHO1 can associate with both microtubule and actin cytoskeletons [2].
  • Analysis of the chicken genomic sequence showed that heterogeneity is derived from alternative splicing, and exon 18 is expressed in only the CHO1 isoform [2].
  • Specifically, cytoplasmic dynein and the kinesin-related motor known as CHO1/MKLP1 are used within the mitotic spindle, and recent studies suggest that they are also essential for the establishment of the axonal and dendritic microtubule arrays of the neuron [3].
  • Using embryonic primary cultures, we demonstrate that CHO-1 mediates hemicholinium-3-sensitive, high-affinity choline uptake that can be enhanced with depolarization in a Ca(2+)-dependent manner supporting ACh synthesis [1].
  • Our findings establish a requirement for presynaptic choline transport activity in vivo in a model amenable to a genetic dissection of CHO-1 regulation [1].

References

  1. The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. Matthies, D.S., Fleming, P.A., Wilkes, D.M., Blakely, R.D. J. Neurosci. (2006) [Pubmed]
  2. CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis. Kuriyama, R., Gustus, C., Terada, Y., Uetake, Y., Matuliene, J. J. Cell Biol. (2002) [Pubmed]
  3. Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development. Ferhat, L., Cook, C., Chauviere, M., Harper, M., Kress, M., Lyons, G.E., Baas, P.W. J. Neurosci. (1998) [Pubmed]
 
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