Disease relevance of Neurobiology

• The emerging neurobiology of SGP-2 encompasses the subjects of cell death, synaptic remodelling, neuroendocrinology and neurodegenerative diseases [1].
• The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder [2].
• OBJECTIVE: To outline recent developments in the neurobiology of the tuberous sclerosis complex (TSC) [3].
• This neurotransmitter is involved in the control of movement and Parkinson's disease, the neurobiology and symptoms of schizophrenia and attention deficit hyperactivity disorder [4].
• The sympathetic neurobiology of essential hypertension: disparate influences of obesity, stress, and noradrenaline transporter dysfunction [5]?

Psychiatry related information on Neurobiology

• Much data has accumulated over the past decade supporting the hypothesis that CCK plays a role in the neurobiology of anxiety and panic attacks [6].
• Additionally, melatonin, a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology [7].
• These results also suggest the possibility that the neurotransmitters glutamate and GABA may be involved in the neurobiology of generalized social phobia [8].
• Abnormalities of PSD95-like molecules and other intracellular signaling machinery may contribute to dysregulated communication between multiple neurotransmitter systems (such as glutamatergic and dopaminergic systems) that are potentially involved in the neurobiology of schizophrenia and affective disorders [9].
• In Alzheimer's disease, cognitive decline is associated with loss of both glutamatergic and cholinergic neurones (Francis et al., 1992, Progress in Neurobiology 39, 517-545) [10].

High impact information on Neurobiology

• An EMBO-sponsored workshop entitled "Translational Control in Development and Neurobiology" was held recently in Mallorca, Spain. The talks covered mechanisms of translational regulation, particularly in terms of temporal and spatial regulation, over a wide range of biological systems [11].
• This data allowed us to identify mRNAs encoding proteins involved in synaptic or developmental neurobiology that harbor FMRP binding elements [12].
• Neurobiology: Dopamine as chicken and egg [13].
• Neurobiology: serotonin sustains serenity [14].
• Neurobiology: glutamate receptors on the move [15].

Chemical compound and disease context of Neurobiology

• Generalizability of the findings is limited by small number of subjects, male gender and veteran status; however, the significantly higher prevalence of smoking among individuals with schizophrenic disorders may support the growing evidence of linkages between the effects of nicotine and the neurobiology of schizophrenia [16].
• 4. These data failed to support the therapeutic role of pimozide in the treatment of delusional disorder and may suggest, when compared to other disorders with prominent delusions such as schizophrenia, a different neurobiology for the illness [17].
• The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected] [18].

Biological context of Neurobiology

• Kallmann syndrome. From genetics to neurobiology [19].
• DATA EXTRACTION: Reports were reviewed by individuals with expertise in serotonin neurobiology, neurotoxicity, neuropsychiatry, and pulmonary medicine and evaluated for appropriateness for inclusion in this review [20].
• Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology [21].
• These two phenotypes share considerable similarity in their neurobiology, including a similar response to nicotine [22].
• Molecular neurobiology for practicing psychiatrists, Part 5: How a leucine zipper can turn on genes: immediate-early genes activate late-gene expression in the brain [23].

Anatomical context of Neurobiology

• We have also provided a brief introduction into how animal models of temporal lobe epilepsy facilitate use of modern state-of-the-art techniques in neurobiology to address critical questions in the pathogenesis of epilepsy [24].
• Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins that is widely expressed in the hippocampal formation and has been implicated in the neurobiology of schizophrenia [25].
• Thus, we have demonstrated that bFGF is a neurotropic factor in GT1 GnRh neuronal cell lines, raising the possibility that bFGF may play a role in the neurobiology of GnRH neurons [26].
• Studies on the neurobiology of cocaine abuse suggest that cocaine directly modifies the activity of dopamine neurons projecting from the dopamine-synthesizing cells of the ventral tegmental area to the nucleus accumbens [27].
• As a result, studies with nicotine have the potential to contribute to our understanding of the neurobiology of addiction which cannot easily be explored using drugs, such as cocaine and amphetamine, which invariably increase dopamine overflow in the forebrain [28].

Associations of Neurobiology with chemical compounds

• Neurobiology: memories of nicotine [29].
• The molecular neurobiology of the acetylcholine receptor [30].
• Molecular neurobiology. NMDA receptors cloned at last [31].
• Neurobiology. Anchoring glycine receptors [32].
• Neurobiology. Neuronal self-reliance [33].

Gene context of Neurobiology

• Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders [34].
• Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has been implicated in the neurobiology of depression [35].
• New developments in the neurobiology of the tuberous sclerosis complex [3].
• Neurobiology of substance P and the NK1 receptor [36].
• Taken together, the confirmation of LRRN6A's expression profile, its predicted protein structure and its similarity to nervous system-expressed LRR proteins with essential roles in nervous system development and maintenance suggest that LRRN6A is a novel gene of relevance in the molecular and cellular neurobiology of vertebrates [37].

Analytical, diagnostic and therapeutic context of Neurobiology

• The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin [38].
• Developing the ideal pharmacotherapy for BPD and SUD can be informed by the role of gamma-aminobutyric acid (GABA) in the neurobiology of SUD [39].
• Organotypic cultures of TM histamine neurons, and co-cultures with their targets, provide a useful model system for studying several aspects of central histaminergic neurobiology [40].
• Carbodiimide as a tissue fixative in histamine immunohistochemistry and its application in developmental neurobiology [41].
• Longitudinal studies of the neurobiology of vitamin E and other antioxidant systems, and neurological function in the vitamin E deficient rat [42].

References