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Gene Review:

Ercc8 - excision repaiross-complementing rodent...

Mus musculus

Synonyms: 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18Rik, Ckn1, ...

Feinstein, R.N. et al., van der Horst, G.T. et al., Gorgels, T.G. et al., Shaffer, J.B. et al., Nahari, D. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ercc8

In contrast to human CS, Csa-/- animals develop skin tumors after chronic exposure to UV light, indicating that TCR in mice protects from UV-induced skin cancer development [1].
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice [1].
In order to determine the molecular basis for Csb acatalasemia, we have isolated a cDNA clone for murine catalase and have used this probe to analyze Csa and Csb genomic DNA and catalase mRNA [2].

High impact information on Ercc8

Importantly, when Csb(m/m) mice (as well as Csa(-/-) mice) were exposed to 10 Gy of ionizing radiation, we noticed an increase in apoptotic photoreceptor cells, which was not observed in wild-type animals [3].
Here we show that this mutation is not a hot spot in Xpa or Csa mutant mice [4].
Some pharmacological and toxicological effects of dietary 3-amino-1,2,4-triazole (AT), a known catalase inhibitor, antithyroid agent, and carcinogen, have been examined, using acatalasemic (Csb) and normal catalase, "wild-type" (Csa) substrains of highly inbred C3H and C57BL mice [5].

References

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. van der Horst, G.T., Meira, L., Gorgels, T.G., de Wit, J., Velasco-Miguel, S., Richardson, J.A., Kamp, Y., Vreeswijk, M.P., Smit, B., Bootsma, D., Hoeijmakers, J.H., Friedberg, E.C. DNA Repair (Amst.) (2002) [Pubmed]
Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. Shaffer, J.B., Sutton, R.B., Bewley, G.C. J. Biol. Chem. (1987) [Pubmed]
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for cockayne syndrome. Gorgels, T.G., van der Pluijm, I., Brandt, R.M., Garinis, G.A., van Steeg, H., van den Aardweg, G., Jansen, G.H., Ruijter, J.M., Bergen, A.A., van Norren, D., Hoeijmakers, J.H., van der Horst, G.T. Mol. Cell. Biol. (2007) [Pubmed]
Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. Nahari, D., McDaniel, L.D., Task, L.B., Daniel, R.L., Velasco-Miguel, S., Friedberg, E.C. DNA Repair (Amst.) (2004) [Pubmed]
Comparative effects of aminotriazole on normal and acatalasemic mice. Feinstein, R.N., Fry, R.J., Staffeldt, E.F. Journal of environmental pathology and toxicology. (1978) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ATCSA-1	Arabidopsis thaliana
AT1G19750	Arabidopsis thaliana
ERCC8	Bos taurus
ERCC8	Canis lupus familiaris
ercc8	Danio rerio
ERCC8	Gallus gallus
ERCC8	Homo sapiens
Os01g0857900	Oryza sativa Japonica Group
ERCC8	Pan troglodytes
Ercc8	Rattus norvegicus
ckn1	Schizosaccharomyces pombe 972h-
ercc8	Xenopus (Silurana) tropicalis

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