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Gene Review

Ercc8  -  excision repaiross-complementing rodent...

Mus musculus

Synonyms: 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, B130065P18Rik, Ckn1, ...
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Disease relevance of Ercc8


High impact information on Ercc8

  • Importantly, when Csb(m/m) mice (as well as Csa(-/-) mice) were exposed to 10 Gy of ionizing radiation, we noticed an increase in apoptotic photoreceptor cells, which was not observed in wild-type animals [3].
  • Here we show that this mutation is not a hot spot in Xpa or Csa mutant mice [4].
  • Some pharmacological and toxicological effects of dietary 3-amino-1,2,4-triazole (AT), a known catalase inhibitor, antithyroid agent, and carcinogen, have been examined, using acatalasemic (Csb) and normal catalase, "wild-type" (Csa) substrains of highly inbred C3H and C57BL mice [5].


  1. UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. van der Horst, G.T., Meira, L., Gorgels, T.G., de Wit, J., Velasco-Miguel, S., Richardson, J.A., Kamp, Y., Vreeswijk, M.P., Smit, B., Bootsma, D., Hoeijmakers, J.H., Friedberg, E.C. DNA Repair (Amst.) (2002) [Pubmed]
  2. Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. Shaffer, J.B., Sutton, R.B., Bewley, G.C. J. Biol. Chem. (1987) [Pubmed]
  3. Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for cockayne syndrome. Gorgels, T.G., van der Pluijm, I., Brandt, R.M., Garinis, G.A., van Steeg, H., van den Aardweg, G., Jansen, G.H., Ruijter, J.M., Bergen, A.A., van Norren, D., Hoeijmakers, J.H., van der Horst, G.T. Mol. Cell. Biol. (2007) [Pubmed]
  4. Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. Nahari, D., McDaniel, L.D., Task, L.B., Daniel, R.L., Velasco-Miguel, S., Friedberg, E.C. DNA Repair (Amst.) (2004) [Pubmed]
  5. Comparative effects of aminotriazole on normal and acatalasemic mice. Feinstein, R.N., Fry, R.J., Staffeldt, E.F. Journal of environmental pathology and toxicology. (1978) [Pubmed]
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