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Gene Review:

TRX-CAT2-1 - transfer RNA-iMet (CAT) 2-1

Homo sapiens

Synonyms: RNTMI, RNTMI2, TRM1, TRMI1, TRNAM2, ...

Riss, T.L. et al., Del Bianco, T. et al., Zeng, Y. et al., Wang, S. et al., Liu, J. et al., et al.

Del Bianco, Borgoni, Del Bianco, Cedaro, Vianello, Danieli, Di Mario,

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Disease relevance of TRNAMI1

We investigate the susceptibility of human renal cell carcinoma (RCC) cells to TRM-1 and HGS-ETR2, 2 human monoclonal agonistic antibodies specific for TRAIL-R1 and TRAIL-R2, respectively [1].

High impact information on TRNAMI1

Trinucleotide repeat polymorphism at the human met-tRNA-i gene 1 (TRMI) [2].
Infected cells gave rise to a clonal epithelial cell line, designated TRM-1 [3].
The approach that we have used to develop TRM-1 should be applicable to isolating cell lines from other stages of human pancreatic development [3].
Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family [4].
Among point mutations in the hTRM1 gene, only those located in conserved regions of hTRM1p completely eliminated modification activity [5].

Biological context of TRNAMI1

AIMS: Performing linkage analysis in the identified family PATIENTS AND METHODS: We examined the segregation of pepsinogens with microsatellite dinucleotide repeat DNA markers along chromosome 11 (D11S480, PYGM) for pepsinogen Group A and along chromosome 6 [D6S105, D6S 1610, TRMI) for pepsinogen Group C [6].

Associations of TRNAMI1 with chemical compounds

After adaptation of the GH4C1 line in TRM-1 for greater than or equal to 20 generations, removal of components gave a less complex mixture containing 15 mM HEPES, 50 micrograms/ml gentamicin, 10 micrograms/ml Tf, 10 nM T3, and 50 microM Etn (designated TRM-2) that supported serial passage of the cells [7].

Other interactions of TRNAMI1

Of the lines evaluated, only the GH1 failed to grow in TRM-1 [7].

Analytical, diagnostic and therapeutic context of TRNAMI1

In contrast, TRM-1 was effective in only 1 primary RCC cell culture [1].

References

Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo. Zeng, Y., Wu, X.X., Fiscella, M., Shimada, O., Humphreys, R., Albert, V., Kakehi, Y. Int. J. Oncol. (2006) [Pubmed]
Trinucleotide repeat polymorphism at the human met-tRNA-i gene 1 (TRMI). Polymeropoulos, M.H., Xiao, H., Rath, D.S., Merril, C.R. Nucleic Acids Res. (1991) [Pubmed]
Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Wang, S., Beattie, G.M., Mally, M.I., Cirulli, V., Itkin-Ansari, P., Lopez, A.D., Hayek, A., Levine, F. Cell transplantation. (1997) [Pubmed]
Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family. Bujnicki, J.M., Leach, R.A., Debski, J., Rychlewski, L. J. Mol. Microbiol. Biotechnol. (2002) [Pubmed]
The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. Liu, J., Strâby, K.B. Nucleic Acids Res. (2000) [Pubmed]
Peptic ulcer inheritance in patients with elevated serum pepsinogen group A levels and without infection of Helicobacter pylori. Del Bianco, T., Borgoni, R., Del Bianco, P., Cedaro, P., Vianello, F., Danieli, G.A., Di Mario, F. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2000) [Pubmed]
Rat pituitary tumor cells in serum-free culture. I. Selection of thyroid hormone-responsive and autonomous cells. Riss, T.L., Stewart, B.H., Sirbasku, D.A. In Vitro Cell. Dev. Biol. (1989) [Pubmed]

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