Disease relevance of USP4

• Unph mRNA levels are consistently elevated in small cell tumors and adenocarcinomas of the lung, suggesting a possible causative role for the gene in the neoplastic process [1].
• CONCLUSIONS: The body weight was a better predictor for unbound carboplatin clearance than body surface area, and UNP and SCr caused a reduction in clearance of unbound carboplatin, as previously reported [2].

High impact information on USP4

• When we examined a panel of lung-derived cell lines for both UNP mRNA and protein expression, we found reduced levels of UNP protein in all four small cell lung carcinoma cell lines tested [3].
• Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors [1].
• (page 1083) merge these two themes by identifying the ubiquitin-specific protease Usp4 as a partner for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interaction allows processing and delivery to the cell surface of newly synthesized A2A receptors, which are otherwise predominantly intracellular [4].
• Chromosomal mapping by fluorescence in situ hybridization and radiation hybrid analyses localized the USP15 gene to chromosome band 12q14, a different location than that of UNP (3p21.3) [5].
• DESIGN: Ten vials of dexamethasone 1 mg/mL were prepared from dexamethasone sodium phosphate injection, USP 4 mg/mL and bacteriostatic NaCl 0.9% injection [6].

Biological context of USP4

• The in vitro release kinetics of diltiazem hydrochloride sustained-release tablets were evaluated using the USP 2 (paddle) and USP 4 (flow-through) apparatus [7].

Anatomical context of USP4

• The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines [3].

Associations of USP4 with chemical compounds

• The f(U) of plasma carboplatin could be predicted as a function of time, infusion rate and covariates affecting CL(U), weight, UNP and SCr [2].

Analytical, diagnostic and therapeutic context of USP4

• Cellular fractionation and immunocytochemistry revealed UNP expression localized primarily in the cytoplasm [3].

References