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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CLIP2  -  CAP-GLY domain containing linker protein 2

Homo sapiens

Synonyms: CAP-Gly domain-containing linker protein 2, CLIP, CLIP-115, CYLN2, Cytoplasmic linker protein 115, ...
 
 
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Disease relevance of CLIP2

 

Psychiatry related information on CLIP2

 

High impact information on CLIP2

  • Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice [3].
  • Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts [4].
  • Cytoplasmic linker protein (CLIP)-170, CLIP-115, and the dynactin subunit p150(Glued) are structurally related proteins, which associate specifically with the ends of growing microtubules (MTs) [5].
  • The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region [1].
  • Using the rat cDNA as a probe we have isolated overlapping cosmids containing the complete murine and part of the human CYLN2 (cytoplasmic linker-2) genes, which encode CLIP-115 [1].
 

Other interactions of CLIP2

  • Using mortality as the endpoint, the area under receiver operating characteristic curve for modified CLIP-2 system was 0.858 compared with 0.812 for modified CLIP-1 (p = 0.013) and 0.782 for original CLIP system (p < 0.001) at 12 months; the area was 0.879, 0.830, and 0.762, respectively (p all < 0.001) at 24 months [6].
 

Analytical, diagnostic and therapeutic context of CLIP2

  • Using a gene-targeting approach, we provide evidence that mice with haploinsufficiency for Cyln2 have features reminiscent of Williams syndrome, including mild growth deficiency, brain abnormalities, hippocampal dysfunction and particular deficits in motor coordination [3].
  • The Clip CLosure In Percutaneous Procedures study was initiated to study the safety and efficacy of the StarClose device in subjects undergoing diagnostic and interventional catheterization procedures [7].

References

  1. The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region. Hoogenraad, C.C., Eussen, B.H., Langeveld, A., van Haperen, R., Winterberg, S., Wouters, C.H., Grosveld, F., De Zeeuw, C.I., Galjart, N. Genomics (1998) [Pubmed]
  2. Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome. van Hagen, J.M., van der Geest, J.N., van der Giessen, R.S., Lagers-van Haselen, G.C., Eussen, H.J., Gille, J.J., Govaerts, L.C., Wouters, C.H., de Coo, I.F., Hoogenraad, C.C., Koekkoek, S.K., Frens, M.A., van Camp, N., van der Linden, A., Jansweijer, M.C., Thorgeirsson, S.S., De Zeeuw, C.I. Neurobiol. Dis. (2007) [Pubmed]
  3. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Hoogenraad, C.C., Koekkoek, B., Akhmanova, A., Krugers, H., Dortland, B., Miedema, M., van Alphen, A., Kistler, W.M., Jaegle, M., Koutsourakis, M., Van Camp, N., Verhoye, M., van der Linden, A., Kaverina, I., Grosveld, F., De Zeeuw, C.I., Galjart, N. Nat. Genet. (2002) [Pubmed]
  4. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Akhmanova, A., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M., De Zeeuw, C.I., Grosveld, F., Galjart, N. Cell (2001) [Pubmed]
  5. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. Lansbergen, G., Komarova, Y., Modesti, M., Wyman, C., Hoogenraad, C.C., Goodson, H.V., Lemaitre, R.P., Drechsel, D.N., van Munster, E., Gadella, T.W., Grosveld, F., Galjart, N., Borisy, G.G., Akhmanova, A. J. Cell Biol. (2004) [Pubmed]
  6. Proposal of a modified Cancer of the Liver Italian Program staging system based on the model for end-stage liver disease for patients with hepatocellular carcinoma undergoing loco-regional therapy. Huo, T.I., Huang, Y.H., Lin, H.C., Wu, J.C., Chiang, J.H., Lee, P.C., Chang, F.Y., Lee, S.D. Am. J. Gastroenterol. (2006) [Pubmed]
  7. The StarClose(R) vascular closure system: Interventional results from the CLIP study. Hermiller, J.B., Simonton, C., Hinohara, T., Lee, D., Cannon, L., Mooney, M., O'shaughnessy, C., Carlson, H., Fortuna, R., Zapien, M., Fletcher, D.R., Didonato, K., Chou, T.M. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2006) [Pubmed]
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