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Gene Review

Clip2  -  CAP-GLY domain containing linker protein 2

Mus musculus

Synonyms: B230327O20, CAP-Gly domain-containing linker protein 2, CLIP-115, Clip1, Cyln2, ...
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Disease relevance of Clip2


High impact information on Clip2

  • Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts [2].
  • In transfected COS-1 cells, CLIP-115 initially accumulates at the distal ends of microtubules and coincides with CLIP-170, indicating that both proteins mark growing microtubule ends [3].
  • Here we provide evidence that efficient binding of CLIP-115 to microtubules is sensitive to phosphorylation and is not mediated by the conserved MTB domains alone, but requires the presence of the basic, serine rich regions in addition to the MTB motifs [3].
  • We are interested in CLIP-115, since this protein is enriched in neuronal dendrites and may operate in the control of brain-specific organelle translocations [3].
  • Comparison of the genomic DNA structure in wildtype and transgenic mice revealed that the transgene integration had induced an approximately 40-kb deletion, starting downstream of the Cyln2 gene and including the first exon of the Gtf2ird1 gene [4].

Anatomical context of Clip2


  1. LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome. Hoogenraad, C.C., Akhmanova, A., Galjart, N., De Zeeuw, C.I. Bioessays (2004) [Pubmed]
  2. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Akhmanova, A., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M., De Zeeuw, C.I., Grosveld, F., Galjart, N. Cell (2001) [Pubmed]
  3. Functional analysis of CLIP-115 and its binding to microtubules. Hoogenraad, C.C., Akhmanova, A., Grosveld, F., De Zeeuw, C.I., Galjart, N. J. Cell. Sci. (2000) [Pubmed]
  4. Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome. Durkin, M.E., Keck-Waggoner, C.L., Popescu, N.C., Thorgeirsson, S.S. Genomics (2001) [Pubmed]
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