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Gene Review

WNT8A  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-8a, Protein Wnt-8d, WNT8D
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Disease relevance of WNT8A


High impact information on WNT8A

  • Here, we investigated expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines by using cDNA-PCR [3].
  • WNT8A and WNT8B mRNAs were down-regulated together in NT2 cells after all-trans retinoic-acid treatment [3].
  • WNT8B mRNA, but not WNT8A mRNA, was significantly up-regulated by beta-estradiol in MCF-7 cells [3].
  • These results strongly suggest that WNT8A might be implicated in development of early embryos as well as germ cell tumors through activation of the WNT - beta-catenin - TCF pathway [2].
  • The WNT8A gene, consisting of at least 6 exons, was found to encode a 351-amino-acid polypeptide with the N-terminal signal peptide, three N-linked glycosylation sites, and conserved amino-acid residues of the WNT family [2].

Analytical, diagnostic and therapeutic context of WNT8A


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