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Gene Review

XPNPEP2  -  X-prolyl aminopeptidase (aminopeptidase P)...

Homo sapiens

Synonyms: AEACEI, APP2, Aminoacylproline aminopeptidase, Membrane-bound APP, Membrane-bound AmP, ...
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Disease relevance of XPNPEP2


High impact information on XPNPEP2


Biological context of XPNPEP2


Associations of XPNPEP2 with chemical compounds


Other interactions of XPNPEP2


  1. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Duan, Q.L., Nikpoor, B., Dube, M.P., Molinaro, G., Meijer, I.A., Dion, P., Rochefort, D., Saint-Onge, J., Flury, L., Brown, N.J., Gainer, J.V., Rouleau, J.L., Agostoni, A., Cugno, M., Simon, P., Clavel, P., Potier, J., Wehbe, B., Benarbia, S., Marc-Aurele, J., Chanard, J., Foroud, T., Adam, A., Rouleau, G.A. Am. J. Hum. Genet. (2005) [Pubmed]
  2. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Réchards, M., Xia, W., Oorschot, V., van Dijk, S., Annaert, W., Selkoe, D.J., Klumperman, J. Traffic (2006) [Pubmed]
  3. Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25. Sprinkle, T.J., Stone, A.A., Venema, R.C., Denslow, N.D., Caldwell, C., Ryan, J.W. Genomics (1998) [Pubmed]
  4. Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2. Sprinkle, T.J., Caldwell, C., Ryan, J.W. Arch. Biochem. Biophys. (2000) [Pubmed]
  5. Guinea pig membrane-bound aminopeptidase P is a member of the proline peptidase family. Denslow, N.D., Ryan, J.W., Nguyen, H.P. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  6. Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. Prueitt, R.L., Ross, J.L., Zinn, A.R. Cytogenet. Cell Genet. (2000) [Pubmed]
  7. Cloning and tissue distribution of human membrane-bound aminopeptidase P. Venema, R.C., Ju, H., Zou, R., Venema, V.J., Ryan, J.W. Biochim. Biophys. Acta (1997) [Pubmed]
  8. Stimulus responses and amyloid precursor protein processing in DAMI megakaryocytes. Davies, T.A., Billingslea, A., Johnson, R., Greenberg, S., Ortiz, M., Long, H., Sgro, K., Tibbles, H., Seetoo, K., Rathbun, W., Schonhorn, J., Simons, E.R. J. Lab. Clin. Med. (1997) [Pubmed]
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