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Gene Review

Rps6  -  ribosomal protein S6

Mus musculus

Synonyms: 40S ribosomal protein S6, Phosphoprotein NP33, S6R
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Disease relevance of Rps6


High impact information on Rps6


Biological context of Rps6


Anatomical context of Rps6


Associations of Rps6 with chemical compounds


Enzymatic interactions of Rps6


Regulatory relationships of Rps6


Other interactions of Rps6


Analytical, diagnostic and therapeutic context of Rps6


  1. Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia. Hamanaka, Y., Mukai, M., Shimamura, M., Kitagawa, T., Nishida, T., Isohashi, F., Ito, T., Nishizawa, Y., Tatsuta, M., Matsuda, H., Inoue, M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes. Hong-Brown, L.Q., Brown, C.R., Lang, C.H. AIDS Res. Hum. Retroviruses (2005) [Pubmed]
  3. S6k1 is not required for Pten-deficient neuronal hypertrophy. Chalhoub, N., Kozma, S.C., Baker, S.J. Brain Res. (2006) [Pubmed]
  4. Increased phosphorylation of a liver ribosomal protein in mice carrying ascites tumours. Leader, D.P. Cancer Lett. (1981) [Pubmed]
  5. Insulin-mediated phosphorylation of ribosomal protein S6 in mouse melanoma cells and melanoma x fibroblast hybrid cells in relation to cell proliferation. Kulkarni, R.K., Straus, D.S. Biochim. Biophys. Acta (1983) [Pubmed]
  6. EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation. Martin-Pérez, J., Siegmann, M., Thomas, G. Cell (1984) [Pubmed]
  7. Regulation of 40S ribosomal protein S6 phosphorylation in Swiss mouse 3T3 cells. Thomas, G., Siegmann, M., Kubler, A.M., Gordon, J., Jimenez de Asua, L. Cell (1980) [Pubmed]
  8. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Chung, J., Grammer, T.C., Lemon, K.P., Kazlauskas, A., Blenis, J. Nature (1994) [Pubmed]
  9. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Sulic, S., Panic, L., Barkic, M., Mercep, M., Uzelac, M., Volarevic, S. Genes Dev. (2005) [Pubmed]
  10. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., Meyuhas, O. Genes Dev. (2005) [Pubmed]
  11. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Ruvinsky, I., Meyuhas, O. Trends Biochem. Sci. (2006) [Pubmed]
  12. Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs. Ferrari, S., Bannwarth, W., Morley, S.J., Totty, N.F., Thomas, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation. Panic, L., Tamarut, S., Sticker-Jantscheff, M., Barkic, M., Solter, D., Uzelac, M., Grabusic, K., Volarevic, S. Mol. Cell. Biol. (2006) [Pubmed]
  14. Hydrogen peroxide mediates Rac1 activation of S6K1. Bae, G.U., Kim, Y.K., Kwon, H.K., Park, J.W., Lee, E.K., Paek, S.J., Choi, W.S., Jung, I.D., Lee, H.Y., Cho, E.J., Lee, H.W., Han, J.W. Exp. Cell Res. (2004) [Pubmed]
  15. Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Calvo, V., Crews, C.M., Vik, T.A., Bierer, B.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  16. Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester. Tabarini, D., Heinrich, J., Rosen, O.M. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  17. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Jefferies, H.B., Reinhard, C., Kozma, S.C., Thomas, G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells. Ballou, L.M., Jenö, P., Thomas, G. J. Biol. Chem. (1988) [Pubmed]
  19. Insulin-sensitive, serum-sensitive protein kinase activity that phosphorylates ribosomal protein S6 in cultured fibroblast-melanoma hybrid cells. Hecht, L.B., Straus, D.S. Endocrinology (1986) [Pubmed]
  20. Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells. Jenö, P., Jäggi, N., Luther, H., Siegmann, M., Thomas, G. J. Biol. Chem. (1989) [Pubmed]
  21. The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. Shah, O.J., Kimball, S.R., Jefferson, L.S. Biochem. J. (2002) [Pubmed]
  22. Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice. Crozier, S.J., Sans, M.D., Guo, L., D'Alecy, L.G., Williams, J.A. J. Physiol. (Lond.) (2006) [Pubmed]
  23. cDNA encoding a 59 kDa homolog of ribosomal protein S6 kinase from rabbit liver. Harmann, B., Kilimann, M.W. FEBS Lett. (1990) [Pubmed]
  24. Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus. Fry, M.J., Gebhardt, A., Parker, P.J., Foulkes, J.G. EMBO J. (1985) [Pubmed]
  25. Epidermal growth factor-mediated activation of an S6 kinase in Swiss mouse 3T3 cells. Novak-Hofer, I., Thomas, G. J. Biol. Chem. (1985) [Pubmed]
  26. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. Lin, T.A., Kong, X., Saltiel, A.R., Blackshear, P.J., Lawrence, J.C. J. Biol. Chem. (1995) [Pubmed]
  27. Protease-activated kinase II as the mediator of epidermal growth factor-stimulated phosphorylation of ribosomal protein S6. Perisic, O., Traugh, J.A. FEBS Lett. (1985) [Pubmed]
  28. Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. Crews, C.M., Alessandrini, A.A., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M.C., Rafii, S., Pandolfi, P.P. Nature (2006) [Pubmed]
  30. Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Chung, J., Pelech, S.L., Blenis, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  31. Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. Cobb, M.H., Rosen, O.M. J. Biol. Chem. (1983) [Pubmed]
  32. Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters. Morley, S.J., Traugh, J.A. J. Biol. Chem. (1990) [Pubmed]
  33. Structural characterization of the mouse ribosomal protein S6-encoding gene. Pata, I., Metspalu, A. Gene (1996) [Pubmed]
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