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MeSH Review

Semliki Forest Virus

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Disease relevance of Semliki Forest Virus


High impact information on Semliki Forest Virus

  • Replicative form of Semliki Forest virus RNA contains an unpaired guanosine [6].
  • PrP co-localizes with LRP/LR on the surface of N2a cells and Semliki Forest virus (SFV) RNA transfected BHK cells [7].
  • In order to evaluate the role of this layer in different kinetic components of secretion, we used the Semliki Forest virus (SFV) system to infect adrenal chromaffin cells with SNAP-25 Q174L, a point mutant in the zero layer [8].
  • Wild-type and mutant versions of human APP were expressed in hippocampal neurons using the Semliki forest virus system [9].
  • We have compared the behavior of wild-type mouse NEDD-2, a neural precursor cell-expressed, developmentally down-regulated cysteine protease gene, to various mutant forms of the gene in both apoptotic activity in neuronal cells and proteolytic cleavage in the Semliki Forest virus and rabbit reticulocyte protein expression systems [10].

Chemical compound and disease context of Semliki Forest Virus


Biological context of Semliki Forest Virus


Anatomical context of Semliki Forest Virus


Gene context of Semliki Forest Virus

  • (iii) Reconstituted HLA-A and HLA-B vesicles interact in solution with Semliki Forest virus (or with vesicles containing viral spike proteins), as demonstrated by coprecipitation with antisera [24].
  • The proteins coded for by the HLA-A and HLA-B loci in man and the H-2K and H-2D loci in mice were identified as cell surface receptors for Semliki Forest virus [24].
  • As compared with APP-WT (primary neurons from control or PS1-deficient mice infected with Semliki Forest virus), PS1-/- neurons and PS1+/+ neurons overexpressing APP-Deltact (a slow-internalizing mutant) show a decrease of all secreted Abeta peptide species, as expected, because this mutant is processed mainly by alpha-secretase [25].
  • As such, the current study presents a new delivery system that can simultaneously express three anti-tumor genes using a Semliki Forest virus (SFV) vector in the expectation of combined or synergistic effects of angiogenesis inhibition by angiostatin and apoptosis induction by p53, PTEN and the rSFV particle itself [26].
  • This report describes the construction, characterization and the in vivo immunotherapeutic potential of recombinant Semliki Forest virus (SFV) expressing the HPV16 E6 and E7 proteins (SFV-E6E7) [27].

Analytical, diagnostic and therapeutic context of Semliki Forest Virus


  1. Spike--nucleocapsid interaction in Semliki Forest virus reconstructed using network antibodies. Vaux, D.J., Helenius, A., Mellman, I. Nature (1988) [Pubmed]
  2. Co-translational folding of an alphavirus capsid protein in the cytosol of living cells. Nicola, A.V., Chen, W., Helenius, A. Nat. Cell Biol. (1999) [Pubmed]
  3. Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells. Palokangas, H., Metsikkö, K., Väänänen, K. J. Biol. Chem. (1994) [Pubmed]
  4. Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. Olkkonen, V.M., Dupree, P., Killisch, I., Lütcke, A., Zerial, M., Simons, K. J. Cell. Sci. (1993) [Pubmed]
  5. Furin processing and proteolytic activation of Semliki Forest virus. Zhang, X., Fugère, M., Day, R., Kielian, M. J. Virol. (2003) [Pubmed]
  6. Replicative form of Semliki Forest virus RNA contains an unpaired guanosine. Wengler, G., Wengler, G., Gross, H.S. Nature (1979) [Pubmed]
  7. The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. Gauczynski, S., Peyrin, J.M., Haïk, S., Leucht, C., Hundt, C., Rieger, R., Krasemann, S., Deslys, J.P., Dormont, D., Lasmézas, C.I., Weiss, S. EMBO J. (2001) [Pubmed]
  8. Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25. Wei, S., Xu, T., Ashery, U., Kollewe, A., Matti, U., Antonin, W., Rettig, J., Neher, E. EMBO J. (2000) [Pubmed]
  9. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. Tienari, P.J., De Strooper, B., Ikonen, E., Simons, M., Weidemann, A., Czech, C., Hartmann, T., Ida, N., Multhaup, G., Masters, C.L., Van Leuven, F., Beyreuther, K., Dotti, C.G. EMBO J. (1996) [Pubmed]
  10. Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis. Allet, B., Hochmann, A., Martinou, I., Berger, A., Missotten, M., Antonsson, B., Sadoul, R., Martinou, J.C., Bernasconi, L. J. Cell Biol. (1996) [Pubmed]
  11. Cholesterol is required for infection by Semliki Forest virus. Phalen, T., Kielian, M. J. Cell Biol. (1991) [Pubmed]
  12. Membrane fusion of Semliki Forest virus in a model system: correlation between fusion kinetics and structural changes in the envelope glycoprotein. Bron, R., Wahlberg, J.M., Garoff, H., Wilschut, J. EMBO J. (1993) [Pubmed]
  13. Dissection of the Golgi complex. II. Density separation of specific Golgi functions in virally infected cells treated with monensin. Quinn, P., Griffiths, G., Warren, G. J. Cell Biol. (1983) [Pubmed]
  14. The signal sequence of the p62 protein of Semliki Forest virus is involved in initiation but not in completing chain translocation. Garoff, H., Huylebroeck, D., Robinson, A., Tillman, U., Liljeström, P. J. Cell Biol. (1990) [Pubmed]
  15. The effect of colchicine and dibucaine on the morphogenesis of Semliki Forest virus. Richardson, C.D., Vance, D.E. J. Biol. Chem. (1978) [Pubmed]
  16. Elimination of phosphorylation sites of Semliki Forest virus replicase protein nsP3. Vihinen, H., Ahola, T., Tuittila, M., Merits, A., Kääriäinen, L. J. Biol. Chem. (2001) [Pubmed]
  17. A procedure to verify an amino acid sequence which has been derived from a nucleotide sequence: application to the 26S RNA of Semliki Forest virus. Garoff, H., Riedel, H., Lehrach, H. Nucleic Acids Res. (1982) [Pubmed]
  18. Replicon vectors derived from Sindbis virus and Semliki forest virus that establish persistent replication in host cells. Perri, S., Driver, D.A., Gardner, J.P., Sherrill, S., Belli, B.A., Dubensky, T.W., Polo, J.M. J. Virol. (2000) [Pubmed]
  19. Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. Griffiths, G., Quinn, P., Warren, G. J. Cell Biol. (1983) [Pubmed]
  20. Dissection of Semliki Forest virus glycoprotein delivery from the trans-Golgi network to the cell surface in permeabilized BHK cells. de Curtis, I., Simons, K. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  21. Cell-free fatty acid acylation of Semliki Forest viral polypeptides with microsomal membranes from eukaryotic cells. Berger, M., Schmidt, M.F. J. Biol. Chem. (1984) [Pubmed]
  22. Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells. Forman, M.S., Cook, D.G., Leight, S., Doms, R.W., Lee, V.M. J. Biol. Chem. (1997) [Pubmed]
  23. Chemical cross-linking of proteins of Semliki Forest virus: virus particles and plasma membranes from BHK-21 cells treated with colchicine or dibucaine. Richardson, C.D., Vance, D.E. J. Virol. (1978) [Pubmed]
  24. Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Helenius, A., Morein, B., Fries, E., Simons, K., Robinson, P., Schirrmacher, V., Terhorst, C., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  25. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. Wiltfang, J., Esselmann, H., Cupers, P., Neumann, M., Kretzschmar, H., Beyermann, M., Schleuder, D., Jahn, H., Rüther, E., Kornhuber, J., Annaert, W., De Strooper, B., Saftig, P. J. Biol. Chem. (2001) [Pubmed]
  26. Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. Lee, J.S., Lee, J.H., Poo, H., Kim, M.S., Lee, S.H., Sung, M.H., Kim, C.J. Int. J. Oncol. (2006) [Pubmed]
  27. Genetic immunization against cervical carcinoma: induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7. Daemen, T., Pries, F., Bungener, L., Kraak, M., Regts, J., Wilschut, J. Gene Ther. (2000) [Pubmed]
  28. Biogenesis of the Semliki Forest virus RNA replication complex. Kujala, P., Ikäheimonen, A., Ehsani, N., Vihinen, H., Auvinen, P., Kääriäinen, L. J. Virol. (2001) [Pubmed]
  29. Solubilization of the Semliki Forest virus membrane with sodium dodecyl sulfate. Becker, R., Helenius, A., Simons, K. Biochemistry (1975) [Pubmed]
  30. Sequence analysis of lactosamine type glycans of individual membrane proteins of Semliki Forest virus. Pesonen, M. J. Gen. Virol. (1979) [Pubmed]
  31. Localization of actin in Moloney murine leukemia virus by immunoelectron microscopy. Nermut, M.V., Wallengren, K., Pager, J. Virology (1999) [Pubmed]
  32. Gene targeting in human somatic cells. Complete inactivation of an interferon-inducible gene. Porter, A.C., Itzhaki, J.E. Eur. J. Biochem. (1993) [Pubmed]
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