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Gene Review

Tbx18  -  T-box18

Mus musculus

Synonyms: 2810012F10Rik, 2810404D13Rik, T-box protein 18, T-box transcription factor TBX18
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Disease relevance of Tbx18


High impact information on Tbx18

  • Ectopic expression experiments suggest that Tbx18 can promote anterior at the expense of posterior somite compartments [2].
  • Tbx18 regulates the development of the ureteral mesenchyme [3].
  • The gene encoding the T-box transcription factor Tbx18 was expressed in undifferentiated mesenchymal cells surrounding the distal ureter stalk [3].
  • The T-box transcription factor encoding gene, Tbx18, is expressed in the left ventricle and left side of the developing IVS, providing additional support for the presence of left and right ventricular identities within the IVS [4].
  • Given the haploinsufficiency phenotypes reported for other T-box genes, we speculate that AI may influence the function of Tbx18 during osteosarcomagenesis [1].

Anatomical context of Tbx18


Other interactions of Tbx18

  • Cloning and expression analysis of the mouse T-box gene Tbx18 [6].
  • Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18 [5].

Analytical, diagnostic and therapeutic context of Tbx18


  1. Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma. Rosemann, M., Kuosaite, V., Nathrath, M., Strom, T.M., Quintanilla-Martinez, L., Richter, T., Imai, K., Atkinson, M.J. Carcinogenesis (2003) [Pubmed]
  2. The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Bussen, M., Petry, M., Schuster-Gossler, K., Leitges, M., Gossler, A., Kispert, A. Genes Dev. (2004) [Pubmed]
  3. Tbx18 regulates the development of the ureteral mesenchyme. Airik, R., Bussen, M., Singh, M.K., Petry, M., Kispert, A. J. Clin. Invest. (2006) [Pubmed]
  4. Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart. Franco, D., Meilhac, S.M., Christoffels, V.M., Kispert, A., Buckingham, M., Kelly, R.G. Dev. Biol. (2006) [Pubmed]
  5. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Christoffels, V.M., Mommersteeg, M.T., Trowe, M.O., Prall, O.W., de Gier-de Vries, C., Soufan, A.T., Bussen, M., Schuster-Gossler, K., Harvey, R.P., Moorman, A.F., Kispert, A. Circ. Res. (2006) [Pubmed]
  6. Cloning and expression analysis of the mouse T-box gene Tbx18. Kraus, F., Haenig, B., Kispert, A. Mech. Dev. (2001) [Pubmed]
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