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Gene Review

PXDN  -  peroxidasin

Homo sapiens

Synonyms: COPOA, D2S448, D2S448E, KIAA0230, MG50, ...
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Disease relevance of PXDN


High impact information on PXDN


Chemical compound and disease context of PXDN


Biological context of PXDN


Associations of PXDN with chemical compounds

  • The rate of platinum accumulation at an equimolar concentration of cisplatin was 41M > SKOV-3 > CH1 > PXN/94 > HX/62 [4].
  • Only one of the six parent tumour lines (PXN/100) was markedly sensitive to tetraplatin [6].
  • In contrast, in one of three lines with derived resistance to the platinum (IV) agent, CHIP, (PXN/951) a retention in sensitivity was observed with CDDP and CBDCA [6].


  1. A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes. Mitchell, M.S., Kan-Mitchell, J., Minev, B., Edman, C., Deans, R.J. Cancer Res. (2000) [Pubmed]
  2. The role of glutathione (GSH) in determining sensitivity to platinum drugs in vivo in platinum-sensitive and -resistant murine leukaemia and plasmacytoma and human ovarian carcinoma xenografts. Goddard, P., Valenti, M., Kelland, L.R. Anticancer Res. (1994) [Pubmed]
  3. Adsorption column for myasthenia gravis treatment: Medisorba MG-50. Nakaji, S., Hayashi, N. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. (2003) [Pubmed]
  4. Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcinoma cell lines. Mistry, P., Kelland, L.R., Loh, S.Y., Abel, G., Murrer, B.A., Harrap, K.R. Cancer Res. (1992) [Pubmed]
  5. Pre-clinical development of the anti-tumour agent CB 7646, bis N-(hydroxymethyl) trimethylmelamine, a stable analogue of trimelamol. Coley, H.M., Jarman, M., Brooks, N., Kubota, T., Goddard, P.M., Jones, M., Lee, N., Owens, M.D., Halbert, G.W., Judson, I.R. Int. J. Cancer (1996) [Pubmed]
  6. Acquisition of platinum drug resistance and platinum cross resistance patterns in a panel of human ovarian carcinoma xenografts. Jones, M., Siracky, J., Kelland, L.R., Harrap, K.R. Br. J. Cancer (1993) [Pubmed]
  7. Assignment of a human melanoma associated gene MG50 (D2S448) to chromosome 2p25.3 by fluorescence in situ hybridization. Weiler, S.R., Taylor, S.M., Deans, R.J., Kan-Mitchell, J., Mitchell, M.S., Trent, J.M. Genomics (1994) [Pubmed]
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