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Gene Review:

Pxn - Peroxidasin

Drosophila melanogaster

Synonyms: CG12002, CT1239, DmPxd-a, Dmel\CG12002, Dpxn, ...

Nelson, R.E. et al., Sritunyalucksana, K. et al., Qadri, I. et al., Alfonso, T.B. et al.

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High impact information on Pxn

Cultured cells secrete peroxidasin; it occurs in larvae and adults [1].
Hemocytes differentiate early from head mesoderm, make peroxidasin and later phagocytose apoptotic cells [1].
As hemocytes spread throughout the embryo, they synthesize extracellular matrix and peroxidasin, incorporating it into completed basement membranes [1].
These results provide an explanation for the promiscuous behavior of pX in the transactivation of a large repertoire of cellular promoters [2].
These Peroxidasin-expressing hemocytes fail to migrate to their normal locations and do not complete their conversion into macrophages [3].

Anatomical context of Pxn

The shrimp peroxinectin cDNA also shows similarity (51%) to both Drosophila peroxinectin-related protein (AAF78217) and peroxidasin (S46224), an extracellular matrix protein combining an active peroxidase domain as well as immunoglobulin domains, leucine rich repeats and procollagen-like motif [4].

References

Peroxidasin: a novel enzyme-matrix protein of Drosophila development. Nelson, R.E., Fessler, L.I., Takagi, Y., Blumberg, B., Keene, D.R., Olson, P.F., Parker, C.G., Fessler, J.H. EMBO J. (1994) [Pubmed]
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Qadri, I., Maguire, H.F., Siddiqui, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Alfonso, T.B., Jones, B.W. Dev. Biol. (2002) [Pubmed]
Peroxinectin, a cell adhesive protein associated with the proPO system from the black tiger shrimp, Penaeus monodon. Sritunyalucksana, K., Wongsuebsantati, K., Johansson, M.W., Söderhäll, K. Dev. Comp. Immunol. (2001) [Pubmed]

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HPX4	Anopheles gambiae str. PEST
PXDN	Bos taurus
pxn-1	Caenorhabditis elegans
pxn-2	Caenorhabditis elegans
PXDN	Canis lupus familiaris
PXDN	Gallus gallus
PXDN	Homo sapiens
Pxdn	Mus musculus
LOC458999	Pan troglodytes
Pxdn	Rattus norvegicus
pxdn	Xenopus (Silurana) tropicalis

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