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Gene Review

CACNB4  -  calcium channel, voltage-dependent, beta 4...

Homo sapiens

Synonyms: CAB4, CACNLB4, Calcium channel voltage-dependent subunit beta 4, EA5, EIG9, ...
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Disease relevance of CACNB4

  • CONCLUSIONS: EA5 in combination with paclitaxel decreased tumor growth in an orthotopic ovarian cancer mouse model through antiangiogenic mechanisms associated with reduced levels of VEGF and phosphorylated Src [1].

High impact information on CACNB4

  • MATERIALS AND METHODS: Complement-mediated and complement-independent activity of ATG-Fresenius and Alemtuzumab was investigated on four myeloma cell lines (RPMI-8226, U266, KMS-12-BM, and EJM) and bone marrow samples from six myeloma patients [2].
  • Three mAb (G28-5, M2 and M3) mimicked sCD40LT in its ability to promote strong homotypic adhesion in resting B cells, whereas others (EA5, BL-OGY/C4 and 5C3) failed to stimulate strong clustering [3].
  • The 13 coding exons of CACNB4 span >55 kb of genomic DNA [4].
  • The 1560-bp open reading frame of the CACNB4 cDNA predicts a 58-kDa protein with an amino acid sequence that is 99% identical to the rat protein [4].
  • Expression of CACNB4 was detected in cerebellum, kidney, testis, retina, lymphoblasts, and circulating lymphocytes [4].

Biological context of CACNB4


Other interactions of CACNB4

  • Cab3, Cab4, and Cab5 mRNAs were detected in all stages examined during soybean development but their levels underwent differential changes [5].
  • Some part of the LASP2/ NEBL-TEM7L-ARL8-CACNB2 locus on 10p12 was paralogous to the LASP1-TEM7-CACNB1 locus on 17q12, while the other part of the LASP2/NEBL-TEM7L-ARL8-CACNB2 locus was paralogous to the NEB-ARL5-CACNB4 locus on 2q23 [6].

Analytical, diagnostic and therapeutic context of CACNB4

  • Combination therapy with EA5 and paclitaxel reduced tumor weight by 77% and 80% (95% CI = 63% to 91% and 68% to 91%), respectively, compared with paclitaxel alone and by 92% and 88% (95% CI = 87% to 97% and 80% to 94%), respectively, compared with IgG alone [1].


  1. Efficacy and Antivascular Effects of EphA2 Reduction With an Agonistic Antibody in Ovarian Cancer. Landen, C.N., Lu, C., Han, L.Y., Coffman, K.T., Bruckheimer, E., Halder, J., Mangala, L.S., Merritt, W.M., Lin, Y.G., Gao, C., Schmandt, R., Kamat, A.A., Li, Y., Thaker, P., Gershenson, D.M., Parikh, N.U., Gallick, G.E., Kinch, M.S., Sood, A.K. J. Natl. Cancer Inst. (2006) [Pubmed]
  2. Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells. Ayuk, F.A., Fang, L., Fehse, B., Zander, A.R., Kröger, N. Exp. Hematol. (2005) [Pubmed]
  3. Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells. Pound, J.D., Challa, A., Holder, M.J., Armitage, R.J., Dower, S.K., Fanslow, W.C., Kikutani, H., Paulie, S., Gregory, C.D., Gordon, J. Int. Immunol. (1999) [Pubmed]
  4. Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. Escayg, A., Jones, J.M., Kearney, J.A., Hitchcock, P.F., Meisler, M.H. Genomics (1998) [Pubmed]
  5. Chlorophyll a/b-binding protein genes are differentially expressed during soybean development. Chang, Y.C., Walling, L.L. Plant Mol. Biol. (1992) [Pubmed]
  6. Identification and characterization of LASP2 gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
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