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Gene Review

TNIP2  -  TNFAIP3 interacting protein 2

Homo sapiens

Synonyms: A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, ABIN2, FLIP1, Fetal liver LKB1-interacting protein, ...
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Disease relevance of TNIP2


High impact information on TNIP2


Biological context of TNIP2

  • Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis [2].
  • We have also found that BAF60a, a component of chromatin-remodeling complex, interacts with ABIN-2 by the yeast two-hybrid analysis [4].
  • Here we report that ABIN-2 has the potential to enter the nucleus and plays a role in mediating transcriptional activation in both yeast and mammalian cells [4].
  • In the first part of this work [Heinrich, R., Montero, F., Klipp, E., Waddell, T. G. & Melendez-Hevia, E. (1997) Eur. J. Biochem. 243, 191-201] the kinetic and thermodynamic constraints under which an optimal glycolysis must be designed have been analysed [5].

Anatomical context of TNIP2

  • The inhibitors of phosphatidylinositol-3 kinase, wortmannin and LY294002, suppressed ABIN-2 inhibition of endothelial cell death [2].
  • Coexpression of Tie2 and ABIN-2 in CHO cells confirmed the interaction occurs in mammalian cells [6].
  • The L6 skeletal muscle cell line has been identified as a suitable model to study the action of insulin on glucose uptake in muscle [Klip, Li & Logan (1984) Am. J. Physiol. 247, E291-E296] [7].

Associations of TNIP2 with chemical compounds

  • The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 [6].
  • The tumorigenic inflammatory and anti-apoptotic effects of NFkappaB are inhibited by progesterone/PRB through the transcriptional control of binding proteins A20 and ABIN-2 [1].
  • Immunostaining for putative targets of NF-kappaB was as follows: Bcl-xL, 76.2% (p = 0.001); Flip 43.0%; Cyclin D1, 64.79%. p65 immunostaining correlated with increased immunoreaction for steroid hormone receptors [8].
  • The PED PAH concentrations were also used to calculate porewater PAH concentrations that allowed for the estimation of a linear free-energy relationship between the lipid-water distribution coefficient (Klip) and the octanol-water distribution coefficient (KOW) for PAH uptake in marine polychaetes (R2 = 0.94, p < 0.0001) [9].

Physical interactions of TNIP2

  • The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation [4].

Other interactions of TNIP2

  • Here we examine the effects of ABIN-2 on endothelial cell apoptosis and its potential involvement in Tie2-mediated endothelial survival [2].
  • In contrast, Tie1 did not interact with ABIN-2 in the yeast two-hybrid system or mammalian cells [6].
  • In this report, we describe the identification of a putative human LKB1-interacting protein, FLIP1, using the yeast two-hybrid system [10].


  1. Identification of a novel mechanism of NF-kappaB inactivation by progesterone through progesterone receptors in Hec50co poorly differentiated endometrial cancer cells: induction of A20 and ABIN-2. Davies, S., Dai, D., Feldman, I., Pickett, G., Leslie, K.K. Gynecol. Oncol. (2004) [Pubmed]
  2. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. Tadros, A., Hughes, D.P., Dunmore, B.J., Brindle, N.P. Blood (2003) [Pubmed]
  3. Stability of A+U-rich element binding factor 1 (AUF1)-binding messenger ribonucleic acid correlates with the subcellular relocalization of AUF1 in the rat uterus upon estrogen treatment. Arao, Y., Kikuchi, A., Kishida, M., Yonekura, M., Inoue, A., Yasuda, S., Wada, S., Ikeda, K., Kayama, F. Mol. Endocrinol. (2004) [Pubmed]
  4. The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. Chien, C.Y., Liu, W.K., Chou, C.K., Su, J.Y. FEBS Lett. (2003) [Pubmed]
  5. Theoretical approaches to the evolutionary optimization of glycolysis--chemical analysis. Meléndez-Hevia, E., Waddell, T.G., Heinrich, R., Montero, F. Eur. J. Biochem. (1997) [Pubmed]
  6. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Hughes, D.P., Marron, M.B., Brindle, N.P. Circ. Res. (2003) [Pubmed]
  7. Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture. Klip, A., Ramlal, T. Biochem. J. (1987) [Pubmed]
  8. Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma. Pallares, J., Martínez-Guitarte, J.L., Dolcet, X., Llobet, D., Rue, M., Palacios, J., Prat, J., Matias-Guiu, X. J. Pathol. (2004) [Pubmed]
  9. Use of passive samplers to mimic uptake of polycyclic aromatic hydrocarbons by benthic polychaetes. Vinturella, A.E., Burgess, R.M., Coull, B.A., Thompson, K.M., Shine, J.P. Environ. Sci. Technol. (2004) [Pubmed]
  10. An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. Liu, W.K., Chien, C.Y., Chou, C.K., Su, J.Y. J. Biomed. Sci. (2003) [Pubmed]
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