High impact information on GCC1

• GCC88 cDNA encodes a protein of 88 kDa, and GCC185 cDNA encodes a protein of 185 kDa [1].
• TGN38, which recycles between the TGN and plasma membrane, was transported into and out of the GCC88 decorated structures [1].
• The conserved histidine is necessary for Coy1p's activity in cells lacking Gos1p, suggesting that the TMD of these transmembrane Golgi coiled-coil proteins is directly involved in their function [2].
• Collectively these results show that GCC88, GCC185 and p230/golgin245 are recruited to functionally distinct domains of the TGN and are likely to be important for the maintenance of TGN subdomain structure, a critical feature for mediating protein sorting and membrane transport [3].

Anatomical context of GCC1

• GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network [1].
• By immunofluorescence and immunoelectron microscopy GCC88 and GCC185, and the GRIP protein golgin97, are all localized to the TGN of HeLa cells [1].

Other interactions of GCC1

• Overexpression of both full-length GCC185 and GCC88 showed distinct and nonoverlapping structures [3].

References