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Gene Review

GCC1  -  GRIP and coiled-coil domain containing 1

Homo sapiens

Synonyms: FLJ22035, GCC1P, GCC88, GRIP and coiled-coil domain-containing protein 1, Golgi coiled-coil protein 1, ...
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High impact information on GCC1

  • GCC88 cDNA encodes a protein of 88 kDa, and GCC185 cDNA encodes a protein of 185 kDa [1].
  • TGN38, which recycles between the TGN and plasma membrane, was transported into and out of the GCC88 decorated structures [1].
  • The conserved histidine is necessary for Coy1p's activity in cells lacking Gos1p, suggesting that the TMD of these transmembrane Golgi coiled-coil proteins is directly involved in their function [2].
  • Collectively these results show that GCC88, GCC185 and p230/golgin245 are recruited to functionally distinct domains of the TGN and are likely to be important for the maintenance of TGN subdomain structure, a critical feature for mediating protein sorting and membrane transport [3].

Anatomical context of GCC1


Other interactions of GCC1

  • Overexpression of both full-length GCC185 and GCC88 showed distinct and nonoverlapping structures [3].


  1. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. Luke, M.R., Kjer-Nielsen, L., Brown, D.L., Stow, J.L., Gleeson, P.A. J. Biol. Chem. (2003) [Pubmed]
  2. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Gillingham, A.K., Pfeifer, A.C., Munro, S. Mol. Biol. Cell (2002) [Pubmed]
  3. Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. Derby, M.C., van Vliet, C., Brown, D., Luke, M.R., Lu, L., Hong, W., Stow, J.L., Gleeson, P.A. J. Cell. Sci. (2004) [Pubmed]
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