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Gene Review

ARHGAP10  -  Rho GTPase activating protein 10

Homo sapiens

Synonyms: FLJ20896, FLJ41791, GRAF2, GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, ...
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Disease relevance of ARHGAP10


High impact information on ARHGAP10

  • The GAP domain of ARHGAP10 has GAP activity for RhoA and Cdc42 [1].
  • Over expression of PSGAP in fibroblasts results in reorganization of cytoskeletal structures and changes of cellular morphology, which requires rhoGTPase-activating activity [2].
  • PYK2 interacts with PSGAP Src homology 3 domain via the carboxyl-terminal proline-rich sequence [2].
  • Moreover, PSGAP is localized at cell periphery in fibroblasts in a pleckstrin homology domain-dependent manner [2].
  • Furthermore, PS-GAP decreases the stimulation of cell death induced by stabilization of PAK-2p34 [3].

Anatomical context of ARHGAP10


Other interactions of ARHGAP10

  • The full length of Graf2 contains a putative PH domain, a RhoGAP domain, and an SH3 domain as well as Graf [4].
  • The catalytically active form of PKNbeta phosphorylated Graf and Graf2 in vitro [4].

Analytical, diagnostic and therapeutic context of ARHGAP10

  • Sequence analysis shows that XrGAP protein shares 60% overall amino acids identity with a human Rho-GTPase activating protein (ARHGAP10) that is highly expressed in the brain [5].


  1. ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. Sousa, S., Cabanes, D., Archambaud, C., Colland, F., Lemichez, E., Popoff, M., Boisson-Dupuis, S., Gouin, E., Lecuit, M., Legrain, P., Cossart, P. Nat. Cell Biol. (2005) [Pubmed]
  2. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. Ren, X.R., Du, Q.S., Huang, Y.Z., Ao, S.Z., Mei, L., Xiong, W.C. J. Cell Biol. (2001) [Pubmed]
  3. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. Koeppel, M.A., McCarthy, C.C., Moertl, E., Jakobi, R. J. Biol. Chem. (2004) [Pubmed]
  4. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. Shibata, H., Oishi, K., Yamagiwa, A., Matsumoto, M., Mukai, H., Ono, Y. J. Biochem. (2001) [Pubmed]
  5. A putative Xenopus Rho-GTPase activating protein (XrGAP) gene is expressed in the notochord and brain during the early embryogenesis. Kim, J., Shim, S., Choi, S.C., Han, J.K. Gene Expr. Patterns (2003) [Pubmed]
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