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Gene Review

PKN3  -  protein kinase N3

Homo sapiens

Synonyms: PKNBETA, PKNbeta, Protein kinase PKN-beta, Protein-kinase C-related kinase 3, Serine/threonine-protein kinase N3
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Disease relevance of PKN3


High impact information on PKN3

  • Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K [4].
  • PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA) [4].
  • PKNalpha stimulated the activity of PLD1 in the presence of phosphatidylinositol 4,5-bisphosphate in vitro, whereas PKNbeta had a modest effect on the stimulation of PLD1 activity [5].
  • Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha [6].
  • The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library [6].

Biological context of PKN3


Associations of PKN3 with chemical compounds

  • Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha [6].

Enzymatic interactions of PKN3


Other interactions of PKN3


  1. Positive-negative KG cassettes for construction of multi-gene deletions using a single drug marker. Ueki, T., Inouye, S., Inouye, M. Gene (1996) [Pubmed]
  2. PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family. Shibata, H., Oishi, K., Yamagiwa, A., Matsumoto, M., Mukai, H., Ono, Y. J. Biochem. (2001) [Pubmed]
  3. High-throughput functional genomic methods to analyze the effects of dietary lipids. Pusk??s, L.G., M??nesi, D., Feh??r, L.Z., Kitajka, K. Current pharmaceutical biotechnology (2006) [Pubmed]
  4. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. Leenders, F., Möpert, K., Schmiedeknecht, A., Santel, A., Czauderna, F., Aleku, M., Penschuck, S., Dames, S., Sternberger, M., Röhl, T., Wellmann, A., Arnold, W., Giese, K., Kaufmann, J., Klippel, A. EMBO J. (2004) [Pubmed]
  5. PKN regulates phospholipase D1 through direct interaction. Oishi, K., Takahashi, M., Mukai, H., Banno, Y., Nakashima, S., Kanaho, Y., Nozawa, Y., Ono, Y. J. Biol. Chem. (2001) [Pubmed]
  6. Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha. Oishi, K., Mukai, H., Shibata, H., Takahashi, M., Ona, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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