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Gene Review

STRAP  -  serine/threonine kinase receptor...

Homo sapiens

Synonyms: MAP activator with WD repeats, MAWD, PT-WD, Serine-threonine kinase receptor-associated protein, UNR-interacting protein, ...
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Disease relevance of STRAP


High impact information on STRAP

  • We report a cofactor in the p300 coactivator complex, Strap, which has an unusual structure, being composed almost entirely of a tandem series of six tetratricopeptide repeat (TPR) motifs [6].
  • ATM phosphorylates Strap at a serine residue, stabilizing nuclear Strap and facilitating formation of a stress-responsive co-activator complex [3].
  • Here we report a new pathway in which ATM kinase signals the DNA damage response by targeting the transcriptional cofactor Strap [3].
  • In the latter case, unrip is recruited to the active SMN complex via a stable interaction with Gemin7 [7].
  • Our data identify unrip as the first component of the U snRNP assembly machinery that associates with the SMN complex in a compartment-specific way [7].

Biological context of STRAP

  • Using a conventional two-hybrid technique with MAWD as bait protein, a novel full-length cDNA was isolated and sequenced from a human liver cDNA library [8].
  • Targeting Strap to the nucleus reinstates protein stabilization and activates the DNA damage response [3].
  • These results indicate that the nuclear accumulation of Strap is a critical regulator in the damage response, and argue that this function can be assigned to ATM through the DNA damage-dependent phosphorylation of Strap [3].

Anatomical context of STRAP

  • In the cytoplasm, a macromolecular complex containing the survival motor neuron (SMN) protein, Gemin2-8 and Unrip mediates the ATP-dependent assembly of Sm proteins and snRNAs into snRNPs [9].

Other interactions of STRAP


  1. Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer. Matsuda, S., Katsumata, R., Okuda, T., Yamamoto, T., Miyazaki, K., Senga, T., Machida, K., Thant, A.A., Nakatsugawa, S., Hamaguchi, M. Cancer Res. (2000) [Pubmed]
  2. Oncogenic Serine-Threonine Kinase Receptor-Associated Protein Modulates the Function of Ewing Sarcoma Protein through a Novel Mechanism. Anumanthan, G., Halder, S.K., Friedman, D.B., Datta, P.K. Cancer Res. (2006) [Pubmed]
  3. A new effector pathway links ATM kinase with the DNA damage response. Demonacos, C., Krstic-Demonacos, M., Smith, L., Xu, D., O'Connor, D.P., Jansson, M., La Thangue, N.B. Nat. Cell Biol. (2004) [Pubmed]
  4. Strap muscle neurovascular supply. Wang, R.C., Puig, C.M., Brown, D.J. Laryngoscope (1998) [Pubmed]
  5. Strength and pain measures associated with lateral epicondylitis bracing. Wuori, J.L., Overend, T.J., Kramer, J.F., MacDermid, J. Archives of physical medicine and rehabilitation. (1998) [Pubmed]
  6. A TPR motif cofactor contributes to p300 activity in the p53 response. Demonacos, C., Krstic-Demonacos, M., La Thangue, N.B. Mol. Cell (2001) [Pubmed]
  7. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Grimmler, M., Otter, S., Peter, C., Müller, F., Chari, A., Fischer, U. Hum. Mol. Genet. (2005) [Pubmed]
  8. Cloning and sequencing of a novel human gene which encodes a putative hydroxylase. Iriyama, C., Matsuda, S., Katsumata, R., Hamaguchi, M. J. Hum. Genet. (2001) [Pubmed]
  9. Gemin8 is required for the architecture and function of the survival motor neuron complex. Carissimi, C., Saieva, L., Gabanella, F., Pellizzoni, L. J. Biol. Chem. (2006) [Pubmed]
  10. Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. Seong, H.A., Jung, H., Choi, H.S., Kim, K.T., Ha, H. J. Biol. Chem. (2005) [Pubmed]
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