Psychiatry related information on CSPP1

• Some human disorders with identifiable, localized lesions in CSPP circuitry, for example, Huntington's disease, provide direct validation for this cross-species model [1].

High impact information on CSPP1

• Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation [2].
• Taken together, we demonstrate that CSPP is associated with centrosomes and microtubules and may play a role in the regulation of G(1)/S-phase progression and spindle assembly [2].
• Ectopic expression of CSPP in HEK293T cells blocked cell-cycle progression in early G1 phase and in mitosis in a dose-dependent manner [2].
• Inhibition of CSPP gene expression by small interfering RNAs induced cell-cycle arrest/delay in S phase [2].
• The expression of CSPP at the mRNA level was detected in all tested cell lines and in testis tissue [2].

Biological context of CSPP1

• Furthermore, normal mitotic phenotypes were observed in CSPP-L but not in CSPP transfectants [3].
• CSPP-L high-expressing mitotic cells were predominantly characterized by lagging chromosomes or monopolar spindles, in contrast to the predominant multipolar spindles observed with CSPP expression [3].

Anatomical context of CSPP1

• The different effects of CSPP and CSPP-L on microtubule organization in mitosis depend on the coiled-coil mid-domain insertion [3].

References