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Gene Review

EPC1  -  enhancer of polycomb homolog 1 (Drosophila)

Homo sapiens

Synonyms: Enhancer of polycomb homolog 1, Epl1
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High impact information on EPC1

  • Finally, analogous to yeast, a recombinant trimeric complex formed by Tip60, EPC1, and ING3 is sufficient to reconstitute robust nucleosomal HAT activity in vitro [1].
  • The third tumor showed a t(6p;10q;10p) as the sole karyotypic abnormality, leading to the fusion of PHF1 with another partner, the enhancer of polycomb (EPC1) gene from 10p11; EPC1 has hitherto not been associated with neoplasia [2].
  • Furthermore, we identified the proliferation-specific PcG, EZH2, as an EPC1-interacting protein [3].
  • We showed that, both in vitro and in vivo, E2F6, DP1, and EPC1 form a stable core complex with repressive activity [3].
  • Thus we have identified a novel E2F6-PcG complex (E2F6-EPC1) that interacts with EZH2 and may regulate genes required for cell cycle progression [3].

Biological context of EPC1

  • RFP functions as a transcriptional repressor and associates with Enhancer of Polycomb 1 (EPC1), a member of the Polycomb group proteins, and Mi-2beta, a main component of the nucleosome remodeling and deacetylase (NuRD) complex [4].

Anatomical context of EPC1

  • Although RFP is highly expressed as 58- and 68-kDa proteins in mouse testis, the EPC1 CT region more strongly interacted with the 68-kDa form than the EPcA or EPcB region [5].
  • We recently demonstrated that RFP, which belongs to the large B-box RING finger protein family, interacts with Enhancer of Polycomb 1 (EPC1) and functions as a transcriptional repressor in human cultured cells [5].
  • Both RFP and EPC1 proteins are expressed in several mouse tissues including testis, spleen, thymus, adrenal gland, cerebrum, and cerebellum [5].

Analytical, diagnostic and therapeutic context of EPC1

  • In this study, we examined the expression of RFP and EPC1 in mouse tissues by immunoblotting as well as their interaction by a pull-down assay [5].


  1. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon, Y., Selleck, W., Lane, W.S., Tan, S., Côté, J. Mol. Cell. Biol. (2004) [Pubmed]
  2. Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Micci, F., Panagopoulos, I., Bjerkehagen, B., Heim, S. Cancer Res. (2006) [Pubmed]
  3. A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. Attwooll, C., Oddi, S., Cartwright, P., Prosperini, E., Agger, K., Steensgaard, P., Wagener, C., Sardet, C., Moroni, M.C., Helin, K. J. Biol. Chem. (2005) [Pubmed]
  4. PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein. Matsuura, T., Shimono, Y., Kawai, K., Murakami, H., Urano, T., Niwa, Y., Goto, H., Takahashi, M. Exp. Cell Res. (2005) [Pubmed]
  5. Role for O-glycosylation of RFP in the interaction with enhancer of polycomb. Tezel, G., Shimono, Y., Murakumo, Y., Kawai, K., Fukuda, T., Iwahashi, N., Takahashi, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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