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Gene Review

ING3  -  inhibitor of growth family, member 3

Homo sapiens

Synonyms: Eaf4, FLJ20089, HSPC301, ING2, Inhibitor of growth protein 3, ...
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Disease relevance of ING3


High impact information on ING3


Biological context of ING3


Anatomical context of ING3

  • These antibodies bind to different tumor-associated antigens which are present on human breast carcinoma cell lines at 10(5)-10(6) antigens/cell; ING-1 binds to a 40-kD membrane glycoprotein, while ING-2 binds to a glycoprotein of greater than 300 kD [8].

Associations of ING3 with chemical compounds


Other interactions of ING3

  • ING3 protein harbors the PHD domain highly homologous among ING family proteins, in which we previously found mutations in a related gene, ING1 [7].

Analytical, diagnostic and therapeutic context of ING3


  1. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gunduz, M., Nagatsuka, H., Demircan, K., Gunduz, E., Cengiz, B., Ouchida, M., Tsujigiwa, H., Yamachika, E., Fukushima, K., Beder, L., Hirohata, S., Ninomiya, Y., Nishizaki, K., Shimizu, K., Nagai, N. Gene (2005) [Pubmed]
  2. ING3 Promotes UV-induced Apoptosis via Fas/Caspase-8 Pathway in Melanoma Cells. Wang, Y., Li, G. J. Biol. Chem. (2006) [Pubmed]
  3. Nuclear ING2 expression is reduced in human cutaneous melanomas. Lu, F., Dai, D.L., Martinka, M., Ho, V., Li, G. Br. J. Cancer (2006) [Pubmed]
  4. Prognostic significance of nuclear ING3 expression in human cutaneous melanoma. Wang, Y., Dai, D.L., Martinka, M., Li, G. Clin. Cancer Res. (2007) [Pubmed]
  5. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon, Y., Selleck, W., Lane, W.S., Tan, S., Côté, J. Mol. Cell. Biol. (2004) [Pubmed]
  6. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Nagashima, M., Shiseki, M., Pedeux, R.M., Okamura, S., Kitahama-Shiseki, M., Miura, K., Yokota, J., Harris, C.C. Oncogene (2003) [Pubmed]
  7. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Gunduz, M., Ouchida, M., Fukushima, K., Ito, S., Jitsumori, Y., Nakashima, T., Nagai, N., Nishizaki, K., Shimizu, K. Oncogene (2002) [Pubmed]
  8. Chimeric mouse-human anti-carcinoma antibodies that mediate different anti-tumor cell biological activities. Robinson, R.R., Chartier, J., Chang, C.P., Horwitz, A.H., Better, M. Hum. Antibodies Hybridomas (1991) [Pubmed]
  9. Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4. Palacios, A., Garcia, P., Padr??, D., L??pez-Hern??ndez, E., Mart??n, I., Blanco, F.J. FEBS Lett. (2006) [Pubmed]
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