The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Chia1  -  chitinase, acidic 1

Mus musculus

Synonyms: 2200003E03Rik, AMCase, Acidic mammalian chitinase, Chia, YNL
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Chia

  • Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma [1].
  • Increased expression of both chitinases has been observed in different pathological conditions: chitotriosidase in lysosomal lipid storage disorders like Gaucher disease and AMCase in asthmatic lung disease [2].

High impact information on Chia


  1. Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma. Bierbaum, S., Nickel, R., Koch, A., Lau, S., Deichmann, K.A., Wahn, U., Superti-Furga, A., Heinzmann, A. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  2. Marked differences in tissue-specific expression of chitinases in mouse and man. Boot, R.G., Bussink, A.P., Verhoek, M., de Boer, P.A., Moorman, A.F., Aerts, J.M. J. Histochem. Cytochem. (2005) [Pubmed]
  3. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. Boot, R.G., Blommaart, E.F., Swart, E., Ghauharali-van der Vlugt, K., Bijl, N., Moe, C., Place, A., Aerts, J.M. J. Biol. Chem. (2001) [Pubmed]
  4. Cloning of a rat lung fibrogenic factor. Chen, X.H., Xie, Z.H., Sun, S.J., Cai, G. Gene (2006) [Pubmed]
WikiGenes - Universities