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Gene Review

FAC1  -  AMP deaminase

Arabidopsis thaliana

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High impact information on FAC1

  • This report identifies an N-terminal transmembrane domain in Arabidopsis FAC1, explores subcellular fractionation, and presents a 3.3-A globular catalytic domain x-ray crystal structure with a bound herbicide-based transition state inhibitor that provides the first glimpse of a complete AMPD active site [1].
  • Embryonic factor 1 (FAC1) is one of the earliest expressed plant genes and encodes an AMP deaminase (AMPD), which is also an identified herbicide target [1].
  • Screening of ethyl methanesulfonate-mutagenized populations of Arabidopsis led to the identification of EMBRYONIC FACTOR 1 (FAC1), a locus that gives a zygote-lethal phenotype when mutated [2].
  • Although a low level of FAC1 expression was observed in all organs tested, using a reporter construct we observed a significantly increased FAC1 expression in the zygote, early embryo and endosperm [2].
  • Furthermore, during somatic embryogenesis, a high level of FAC1 expression was observed in developing embryos including putative embryogenic cells [2].

Biological context of FAC1

  • Expression of FAC1 in a yeast AMPD mutant after removal of its N-terminal putative transmembrane domain complemented the mutant phenotype, suggesting a functional conservancy but a structural divergence through evolution [2].

Analytical, diagnostic and therapeutic context of FAC1


  1. Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1). Han, B.W., Bingman, C.A., Mahnke, D.K., Bannen, R.M., Bednarek, S.Y., Sabina, R.L., Phillips, G.N. J. Biol. Chem. (2006) [Pubmed]
  2. EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Xu, J., Zhang, H.Y., Xie, C.H., Xue, H.W., Dijkhuis, P., Liu, C.M. Plant J. (2005) [Pubmed]
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