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Gene Review

AMD1  -  AMP deaminase

Saccharomyces cerevisiae S288c

Synonyms: AMD, Myoadenylate deaminase, YML035C
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Disease relevance of AMD1


High impact information on AMD1


Biological context of AMD1


Anatomical context of AMD1


Associations of AMD1 with chemical compounds

  • This report describes 1) the role of AMP deaminase in adenylate metabolism in yeast cell extracts, 2) a method for large scale purification of the enzyme, 3) the kinetic properties of native and proteolyzed enzymes, 4) the kinetic reaction mechanism, and 5) regulatory interactions with ATP, GTP, MgATP, ADP, and PO4 [1].
  • On the basis of these similarities, yeast AMP deaminase is also proposed to use a Zn(2+)-activated water molecule to attack C6 of AMP with the displacement of NH3 [5].
  • The role of fatty acid and citrate on the interaction of the AMP deaminase (EC reaction with glycolysis was investigated using permeabilized yeast cells [9].
  • 4) A simple Michaelis-Menten relationship was observed between the various levels of ammonium ion and of fructose 1,6-biphosphate formed in situ, indicating that phosphofructokinase activity or glycolytic flux was dependent upon the level of ammonium produced through the action of AMP deaminase [10].
  • (b) Linolenate inhibited AMP deaminase activity in situ, resulting in the subsequent decrease in ammonium production, which reduced the activity of 6-phosphofructokinase (EC, whereas linolenate itself had no ability to inhibit the phosphofructokinase activity in the presence of excess ammonium concentration [9].

Regulatory relationships of AMD1


Other interactions of AMD1


Analytical, diagnostic and therapeutic context of AMD1


  1. AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. Merkler, D.J., Wali, A.S., Taylor, J., Schramm, V.L. J. Biol. Chem. (1989) [Pubmed]
  2. Yeast AMP deaminase. Catalytic activity in Schizosaccharomyces pombe and chromosomal location in Saccharomyces cerevisiae. Sollitti, P., Merkler, D.J., Estupiñán, B., Schramm, V.L. J. Biol. Chem. (1993) [Pubmed]
  3. Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. Merkler, D.J., Schramm, V.L. J. Biol. Chem. (1990) [Pubmed]
  4. Mapping the putative RNA helicase genes by sequence overlapping. Chang, T.H., Baum, B. Yeast (1992) [Pubmed]
  5. Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects. Merkler, D.J., Schramm, V.L. Biochemistry (1993) [Pubmed]
  6. Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein. Meyer, S.L., Kvalnes-Krick, K.L., Schramm, V.L. Biochemistry (1989) [Pubmed]
  7. EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Xu, J., Zhang, H.Y., Xie, C.H., Xue, H.W., Dijkhuis, P., Liu, C.M. Plant J. (2005) [Pubmed]
  8. Identification of a noncatalytic domain in AMP deaminase that influences binding to myosin. Marquetant, R., Sabina, R.L., Holmes, E.W. Biochemistry (1989) [Pubmed]
  9. AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate. Yoshino, M., Murakami, K. J. Biol. Chem. (1982) [Pubmed]
  10. AMP deaminase reaction as a control system of glycolysis in yeast. Activation of phosphofructokinase and pyruvate kinase by the AMP deaminase-ammonia system. Yoshino, M., Murakami, K. J. Biol. Chem. (1982) [Pubmed]
  11. Role of AMP deaminase reaction in the control of fructose 1,6-bisphosphatase activity in yeast. Yoshino, M., Murakami, K. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  12. Biochemical and genetic analysis of an alpha-mannosidase mutant from Saccharomyces cerevisiae. Cueva, R., Bordallo, C., Suárez Rendueles, P. FEMS Microbiol. Lett. (1990) [Pubmed]
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