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Gene Review

RR2  -  transcription factor response regulator 2

Arabidopsis thaliana

Synonyms: ARR2, DL4095W, FCAALL.287, response regulator 2
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High impact information on ARR2


Biological context of ARR2


Associations of ARR2 with chemical compounds

  • Thus, the data indicate that ethylene and H(2)O(2) signalling in guard cells are mediated by ETR1 via EIN2 and ARR2-dependent pathway(s), and identify AtrbohF as a key mediator of stomatal responses to ethylene [6].

Other interactions of ARR2

  • Yeast two-hybrid analysis and in vitro interaction studies suggest that ARR2 very probably forms part of a multistep two-component signalling mechanism that includes HPt proteins like AHP1 or AHP2 [5].
  • This motif is highly similar to the optimal DNA-binding sites for ARR1/ARR2, type-B ARRs that have been implicated in the transcriptional elevation of the type-A ARRs [7].
  • Multiple members within this same subfamily of type-B ARRs were expressed near the root tip with highest expression in the root elongation zone. beta-Glucuronidase-fusions to full-length ARR2, ARR12, and ARR19 were nuclear localized, consistent with a role in transcriptional regulation [8].
  • AtARP5, AtARP6, and AtARP8 each have distinct transcript expression patterns in seedlings, roots, leaves, flowers, and siliques [9].


  1. Two-component circuitry in Arabidopsis cytokinin signal transduction. Hwang, I., Sheen, J. Nature (2001) [Pubmed]
  2. The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis. Hass, C., Lohrmann, J., Albrecht, V., Sweere, U., Hummel, F., Yoo, S.D., Hwang, I., Zhu, T., Schäfer, E., Kudla, J., Harter, K. EMBO J. (2004) [Pubmed]
  3. Cytokinin-mediated control of leaf longevity by AHK3 through phosphorylation of ARR2 in Arabidopsis. Kim, H.J., Ryu, H., Hong, S.H., Woo, H.R., Lim, P.O., Lee, I.C., Sheen, J., Nam, H.G., Hwang, I. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Arabidopsis ARR1 and ARR2 response regulators operate as transcriptional activators. Sakai, H., Aoyama, T., Oka, A. Plant J. (2000) [Pubmed]
  5. The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial complex I in Arabidopsis. Lohrmann, J., Sweere, U., Zabaleta, E., Bäurle, I., Keitel, C., Kozma-Bognar, L., Brennicke, A., Schäfer, E., Kudla, J., Harter, K. Mol. Genet. Genomics (2001) [Pubmed]
  6. Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis. Desikan, R., Last, K., Harrett-Williams, R., Tagliavia, C., Harter, K., Hooley, R., Hancock, J.T., Neill, S.J. Plant J. (2006) [Pubmed]
  7. Expression profiling of cytokinin action in Arabidopsis. Rashotte, A.M., Carson, S.D., To, J.P., Kieber, J.J. Plant Physiol. (2003) [Pubmed]
  8. Type-B response regulators display overlapping expression patterns in Arabidopsis. Mason, M.G., Li, J., Mathews, D.E., Kieber, J.J., Schaller, G.E. Plant Physiol. (2004) [Pubmed]
  9. Arabidopsis contains ancient classes of differentially expressed actin-related protein genes. McKinney, E.C., Kandasamy, M.K., Meagher, R.B. Plant Physiol. (2002) [Pubmed]
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