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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

KRP2  -  cyclin-dependent kinase inhibitor 2

Arabidopsis thaliana

Synonyms: ICK2, KIP-RELATED PROTEIN 2, KIP-related protein 2
 
 
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High impact information on ICK2

  • Constitutive overexpression of KRP2 slightly above its endogenous level only inhibited the mitotic cell cycle-specific CDKA;1 kinase complexes, whereas the endoreduplication cycle-specific CDKA;1 complexes were unaffected, resulting in an increase in the DNA ploidy level [1].
  • In accordance with this model, KRP2 protein levels increased in plants with reduced CDKB1;1 activity [1].
  • We illustrate that KRP2 protein abundance is regulated posttranscriptionally through CDK phosphorylation and proteasomal degradation [1].
  • KRP2 appears to regulate early lateral root initiation by blocking the G1-to-S transition and to be regulated transcriptionally by auxin [2].
  • When overproduced, KRP2 dramatically inhibited cell cycle progression in leaf primordia cells without affecting the temporal pattern of cell division and differentiation [3].
 

Biological context of ICK2

  • We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation [3].
  • KRP1 and KRP2 might specifically be involved in the establishment of polyploidy [4].
 

Other interactions of ICK2

  • Outside of this domain, ICK2 is distinct from ICK1, p27Kip1, and other proteins [5].

References

  1. The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes. Verkest, A., Manes, C.L., Vercruysse, S., Maes, S., Van Der Schueren, E., Beeckman, T., Genschik, P., Kuiper, M., Inzé, D., De Veylder, L. Plant Cell (2005) [Pubmed]
  2. Auxin-mediated cell cycle activation during early lateral root initiation. Himanen, K., Boucheron, E., Vanneste, S., de Almeida Engler, J., Inzé, D., Beeckman, T. Plant Cell (2002) [Pubmed]
  3. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. De Veylder, L., Beeckman, T., Beemster, G.T., Krols, L., Terras, F., Landrieu, I., van der Schueren, E., Maes, S., Naudts, M., Inzé, D. Plant Cell (2001) [Pubmed]
  4. Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana. Ormenese, S., de Almeida Engler, J., De Groodt, R., De Veylder, L., Inzé, D., Jacqmard, A. Ann. Bot. (2004) [Pubmed]
  5. The Arabidopsis Cdc2a-interacting protein ICK2 is structurally related to ICK1 and is a potent inhibitor of cyclin-dependent kinase activity in vitro. Lui, H., Wang, H., Delong, C., Fowke, L.C., Crosby, W.L., Fobert, P.R. Plant J. (2000) [Pubmed]
 
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