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Gene Review

CDKB1;1  -  cyclin-dependent kinase B1-1

Arabidopsis thaliana

Synonyms: CDC2-LIKE GENE, CDC2B, CYCLIN-DEPENDENT KINASE B1;1, P34(CDC2)-LIKE PROTEIN, cyclin-dependent kinase B1;1
 
 
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High impact information on CDC2B

  • In accordance with this model, KRP2 protein levels increased in plants with reduced CDKB1;1 activity [1].
  • E2FB regulated the entry into both S- and M-phases, the latter corresponding to the activation of a plant-specific mitotic regulator, CDKB1;1 [2].
  • Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa-overproducing plants and mutational analysis of the E2F binding site in the CDKB1;1 promoter [3].
  • Moreover, when the mutant CDKB1;1 allele was overexpressed in an E2Fa-DPa-overproducing background, it enhanced the endoreduplication phenotype, whereas the extra mitotic cell divisions normally induced by E2Fa-DPa were repressed [3].
  • Because protein levels of both CDKA;1 and CDKB1;1 were not affected, the temporary inhibition of mitotic activity that allows adaptation to the stress condition is most likely mediated by posttranslational control of CDK activity [4].
 

Biological context of CDC2B

  • Genomic Southern-blot analysis with the CDC2a and CDC2b cDNA probes suggested that the A. thaliana genome contains several additional cdc2-like genes, which together with the CDC2a and CDC2b genes may constitute a CDC2 gene family [5].
 

Associations of CDC2B with chemical compounds

  • However, ICK1 was induced by ABA, and along with ICK1 induction there was a decrease in Cdc2-like histone H1 kinase activity [6].

References

  1. The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes. Verkest, A., Manes, C.L., Vercruysse, S., Maes, S., Van Der Schueren, E., Beeckman, T., Genschik, P., Kuiper, M., Inzé, D., De Veylder, L. Plant Cell (2005) [Pubmed]
  2. The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. Magyar, Z., De Veylder, L., Atanassova, A., Bakó, L., Inzé, D., Bögre, L. Plant Cell (2005) [Pubmed]
  3. The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis. Boudolf, V., Vlieghe, K., Beemster, G.T., Magyar, Z., Torres Acosta, J.A., Maes, S., Van Der Schueren, E., Inzé, D., De Veylder, L. Plant Cell (2004) [Pubmed]
  4. Cell cycle modulation in the response of the primary root of Arabidopsis to salt stress. West, G., Inzé, D., Beemster, G.T. Plant Physiol. (2004) [Pubmed]
  5. Identification of two cell-cycle-controlling cdc2 gene homologs in Arabidopsis thaliana. Hirayama, T., Imajuku, Y., Anai, T., Matsui, M., Oka, A. Gene (1991) [Pubmed]
  6. ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis thaliana interacts with both Cdc2a and CycD3, and its expression is induced by abscisic acid. Wang, H., Qi, Q., Schorr, P., Cutler, A.J., Crosby, W.L., Fowke, L.C. Plant J. (1998) [Pubmed]
 
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