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Gene Review:

GPX6 - glutathione peroxidase 6

Arabidopsis thaliana

Synonyms: ATGPX6, LSC803, PHGPX, T5C23.30, T5C23_30

Sugimoto, M. et al., Mullineaux, P.M. et al., Sugimoto, M. et al.

Mullineaux, Karpinski, Jiménez, Cleary, Robinson, Creissen,

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High impact information on ATGPX6

The pea PHGPX has highly conserved homologues in Arabidopsis, citrus and Nicotiana sylvestris and the authors suggest that these proteins are also localised in the chloroplast and not in the cytosol as previously supposed [1].
These results suggest that the putative PHGPX gene is induced by oxidative stress in Arabidopsis [2].

Analytical, diagnostic and therapeutic context of ATGPX6

Southern blot analysis suggested that putative PHGPX gene was a single-copy gene [2].
Northern blot analysis revealed that the Arabidopsis putative PHGPX mRNA levels were increased about 3 and 4.5 times after exposure to NaCl and Al/Fe, respectively [2].
PCR product with the same size as that of the spinach putative PHGPX were obtained from maize, soybeans, and Arabidopsis, suggesting the expression of putative PHGPX genes in other plants [3].

References

Identification of cDNAS encoding plastid-targeted glutathione peroxidase. Mullineaux, P.M., Karpinski, S., Jiménez, A., Cleary, S.P., Robinson, C., Creissen, G.P. Plant J. (1998) [Pubmed]
Putative phospholipid hydroperoxide glutathione peroxidase gene from Arabidopsis thaliana induced by oxidative stress. Sugimoto, M., Sakamoto, W. Genes Genet. Syst. (1997) [Pubmed]
Molecular cloning and characterization of a cDNA encoding putative phospholipid hydroperoxide glutathione peroxidase from spinach. Sugimoto, M., Furui, S., Suzuki, Y. Biosci. Biotechnol. Biochem. (1997) [Pubmed]

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GPXH1	Anopheles gambiae str. PEST
R05H10.5	Caenorhabditis elegans
F26E4.12	Caenorhabditis elegans
gpx4a	Danio rerio
PHGPx	Drosophila melanogaster
Os04g0556300	Oryza sativa Japonica Group
Os02g0664000	Oryza sativa Japonica Group
GPX4	Pan troglodytes

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