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Gene Review:

ACD6 - protein ACCELERATED CELL DEATH 6

Arabidopsis thaliana

Synonyms: ACCELERATED CELL DEATH 6, DL3240W, FCAALL.190

Rate, D.N. et al., Lu, H. et al., Lu, H. et al., Dong, X., Vanacker, H. et al.

Dong,

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Disease relevance of ACD6

Additionally, ACD6 mRNA levels were increased in the systemic, uninfected tissue of Pseudomonas syringae-infected plants as well as in plants treated with the SA agonist benzothiazole (BTH) [1].

High impact information on ACD6

ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response [1].
Thus, ACD6 is a necessary and dose-dependent activator of the defense response against virulent bacteria and can activate SA-dependent cell death [1].
Surprisingly, BTH-treated acd6-nahG plants develop many tumor-like abnormal growths, indicating a possible role for SA in modulating cell growth [2].
The acd6-conferred phenotypes are suppressed by removing a key signaling molecule, salicylic acid (SA), by using the nahG transgene, which encodes SA hydroxylase [2].
A genetic screen for mutants that suppress acd6-1-conferred phenotypes identified 17 intragenic mutations of ACD6 [3].

Biological context of ACD6

ACD6 overexpression confers enhanced disease resistance by priming stronger and quicker defense responses during pathogen infection, plant development or treatment with an agonist of the key defense regulator salicylic acid (SA) [3].
ACD6 is a founding member of a large family of genes that encode proteins with a short amino-terminal region, nine ankyrin repeats in the middle, and five putative transmembrane domains in the carboxyl-terminal region [4].
The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense [4].
The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth [2].
Using acd6-1, agd2 and two other defense-related mutants, lesion simulating disease 6 (lsd6), suppressor of SA-insensitivity (ssi1), we show here in detail that SA regulates cell growth by specifically affecting cell enlargement, endoreduplication and/or cell division [5].

Anatomical context of ACD6

ACD6 localizes to the plasma membrane and is an integral membrane protein with a cytoplasmic ankyrin domain [3].

References

ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response. Lu, H., Rate, D.N., Song, J.T., Greenberg, J.T. Plant Cell (2003) [Pubmed]
The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth. Rate, D.N., Cuenca, J.V., Bowman, G.R., Guttman, D.S., Greenberg, J.T. Plant Cell (1999) [Pubmed]
Structure-function analysis of the plasma membrane- localized Arabidopsis defense component ACD6. Lu, H., Liu, Y., Greenberg, J.T. Plant J. (2005) [Pubmed]
The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense. Dong, X. Sci. STKE (2004) [Pubmed]
A role for salicylic acid and NPR1 in regulating cell growth in Arabidopsis. Vanacker, H., Lu, H., Rate, D.N., Greenberg, J.T. Plant J. (2001) [Pubmed]

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