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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Enlargement

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Disease relevance of Cell Enlargement


High impact information on Cell Enlargement

  • During growth, plant cells secrete a protein called expansin, which unlocks the network of wall polysaccharides, permitting turgor-driven cell enlargement [3].
  • These results imply that the RHD3 protein is a member of a new class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement [4].
  • Organized actin assemblies appeared concomitantly with cell enlargement, promoted by a mechanism that probably does not involve small GTPases of the Rho protein family [5].
  • In CM overexpressing PKG I, NO/cGMP also suppressed BNP induction and cell enlargement but not NFAT activation elicited by constitutively active calcineurin, which is consistent with additional, NFAT-independent inhibitory effect(s) of PKG I downstream of calcineurin [6].
  • When acting with the specific antigen fluorescein-polymerized flagellin, BSF-1 augmented early cell enlargement and markedly enhanced proliferation, but it did not increase the frequency of AFC clones stimulated by fluorescein-polymerized flagellin alone [7].

Biological context of Cell Enlargement


Anatomical context of Cell Enlargement


Associations of Cell Enlargement with chemical compounds

  • In the present work, complete inhibition of proliferation and maximal cell enlargement required exposure to 1 microM methotrexate, whereas colony-forming ability, determined after transfer of cells to drug-free medium, was unaffected over a wide range of concentrations (10(-12)-10(-5) M) [17].
  • Exposure of BeWo cells to fluorodeoxyuridine also stimulated cell enlargement and expression of syncytiotrophoblastic markers, and these effects were blocked by coadministration of thymidine [17].
  • For example, it may carry out some other role more closely related to the function of the auxin hormones in cell enlargement such as protein disulfide-thiol interchange [18].
  • Basal glucose-transport activity increased 6.3-fold/cell but remained constant per unit cellular surface area due to cell enlargement [19].
  • With the help of morphologic studies and using Oil Red detection of cellular lipids, cell enlargement, accumulation of lipid droplets in the cytoplasm, and nuclear fragmentation could be observed under treatment with arachidonic acid [20].

Gene context of Cell Enlargement

  • Changes induced by IL-4 include cell enlargement, increased viability, and increased MHC class II expression [21].
  • Each of these lymphokines induced cell enlargement, flattening, and vesiculation, with gamma IF apparently more potent in this respect than LT or TNF [22].
  • Interleukin 2 did not induce cell enlargement in either the presence or absence of antigen [23].
  • Another, apparently distinct subpopulation, comprising about 25% of the cells, and probably present in xid mice, was sensitive to a proliferative signal delivered by LPS, if the cells had first been cultured for 24 h in the presence of a dose of anti-mu that was sufficient to cause cell enlargement [24].
  • In contrast, the highly specific 5-LO inhibitors BAY X 1005, MK-886 and Wy 50,295 did not inhibit cell enlargement or proliferation [25].

Analytical, diagnostic and therapeutic context of Cell Enlargement


  1. Role of apoptosis for mouse liver growth regulation and tumor promotion: comparative analysis of mice with high (C3H/He) and low (C57Bl/6J) cancer susceptibility. Bursch, W., Grasl-Kraupp, B., Wastl, U., Hufnagl, K., Chabicovsky, M., Taper, H., Schulte-Hermann, R. Toxicol. Lett. (2004) [Pubmed]
  2. Effects of perphenazine and bromocriptine on male accessory sex glands. III. The prostate gland. Krall, A., Spring-Mills, E. Arch. Androl. (1982) [Pubmed]
  3. Loosening of plant cell walls by expansins. Cosgrove, D.J. Nature (2000) [Pubmed]
  4. The ROOT HAIR DEFECTIVE3 gene encodes an evolutionarily conserved protein with GTP-binding motifs and is required for regulated cell enlargement in Arabidopsis. Wang, H., Lockwood, S.K., Hoeltzel, M.F., Schiefelbein, J.W. Genes Dev. (1997) [Pubmed]
  5. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. Cortes-Bratti, X., Chaves-Olarte, E., Lagergård, T., Thelestam, M. J. Clin. Invest. (1999) [Pubmed]
  6. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Fiedler, B., Lohmann, S.M., Smolenski, A., Linnemuller, S., Pieske, B., Schroder, F., Molkentin, J.D., Drexler, H., Wollert, K.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation. Alderson, M.R., Pike, B.L., Nossal, G.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. A role for salicylic acid and NPR1 in regulating cell growth in Arabidopsis. Vanacker, H., Lu, H., Rate, D.N., Greenberg, J.T. Plant J. (2001) [Pubmed]
  9. High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. Sopasakis, V.R., Sandqvist, M., Gustafson, B., Hammarstedt, A., Schmelz, M., Yang, X., Jansson, P.A., Smith, U. Obes. Res. (2004) [Pubmed]
  10. Mechanism of inhibition of lipopolysaccharide-stimulated mouse B-cell responses by transforming growth factor-beta 1. Bouchard, C., Fridman, W.H., Sautès, C. Immunol. Lett. (1994) [Pubmed]
  11. Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Chen, Q.M. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  12. A scanning electron microscopic study of IAA-induced tumors in bean (Phaseolus vulgaris L.) embryos. Sen, S., Stevenson, E.L. Cytobios (1977) [Pubmed]
  13. Differential regulation of surface Ig- and Lyb2-mediated B cell activation by cyclic AMP. I. Evidence for alternative regulation of signaling through two different receptors linked to phosphatidylinositol hydrolysis in murine B cells. Muthusamy, N., Baluyut, A.R., Subbarao, B. J. Immunol. (1991) [Pubmed]
  14. Urotensin II promotes hypertrophy of cardiac myocytes via mitogen-activated protein kinases. Onan, D., Pipolo, L., Yang, E., Hannan, R.D., Thomas, W.G. Mol. Endocrinol. (2004) [Pubmed]
  15. Retinoic acid affects the EGF-R signaling pathway during differentiation induction of human endometrial adenocarcinoma cells. Carter, C.A., Shaw, B.L. Exp. Mol. Pathol. (2000) [Pubmed]
  16. The development of fibrocartilage in the elastic tendon of the chicken wing. Pimentel, S.B., Carvalho, H.F. Anat. Embryol. (2003) [Pubmed]
  17. Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine. Burres, N.S., Cass, C.E. Cancer Res. (1987) [Pubmed]
  18. The hormone-responsive NADH oxidase of the plant plasma membrane has properties of a NADH:protein disulfide reductase. Chueh, P.J., Morré, D.M., Penel, C., DeHahn, T., Morré, D.J. J. Biol. Chem. (1997) [Pubmed]
  19. Role of two types of glucose transporters in enlarged adipocytes from aged obese rats. Ezaki, O., Fukuda, N., Itakura, H. Diabetes (1990) [Pubmed]
  20. Differentiation and apoptosis in human immortalized sebocytes. Wróbel, A., Seltmann, H., Fimmel, S., Müller-Decker, K., Tsukada, M., Bogdanoff, B., Mandt, N., Blume-Peytavi, U., Orfanos, C.E., Zouboulis, C.C. J. Invest. Dermatol. (2003) [Pubmed]
  21. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. Stack, R.M., Lenschow, D.J., Gray, G.S., Bluestone, J.A., Fitch, F.W. J. Immunol. (1994) [Pubmed]
  22. Lymphotoxin, tumor necrosis factor, and gamma interferon are cytostatic for normal human keratinocytes. Symington, F.W. J. Invest. Dermatol. (1989) [Pubmed]
  23. Effects of antigens and lymphokines on early activation of single hapten-specific B lymphocytes. Alderson, M.R., Pike, B.L., Nossal, G.J. J. Immunol. (1987) [Pubmed]
  24. Regulation of growth and proliferation in B cell subpopulations. DeFranco, A.L., Kung, J.T., Paul, W.E. Immunol. Rev. (1982) [Pubmed]
  25. Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. Fedyk, E.R., Phipps, R.P. Int. J. Immunopharmacol. (1994) [Pubmed]
  26. The effects of electrical stimulation of the autonomic nerves and of drugs on the size of salivary glands and their rate of cell division. Muir, T.C., Pollock, D., Turner, C.J. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  27. The xanthomonas type III effector protein AvrBs3 modulates plant gene expression and induces cell hypertrophy in the susceptible host. Marois, E., Van den Ackerveken, G., Bonas, U. Mol. Plant Microbe Interact. (2002) [Pubmed]
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