The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CAPZA1  -  capping protein (actin filament) muscle Z...

Homo sapiens

Synonyms: CAPPA1, CAPZ, CAZ1, CapZ alpha-1, F-actin-capping protein subunit alpha-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CAPZA1

  • Direct binding between CMS/CIN85 and CAPZ provides a link with the actin cytoskeleton [1].
  • Chemical cross-linking, ligand blotting and fluorescence emission spectroscopy reveal that removal of, or mutations within, the sequence encompassing residues 88-90 in the unique C-terminal region of S100A1 interfere with binding to CapZ alpha and to TRTK-12, a synthetic CapZ alpha peptide [2].
  • We have made backbone assignments of the calcium-bound form of S100B and used chemical-shift changes in spectra of 15N-labeled protein to locate the site that binds a peptide corresponding to residues 265-276 from CapZ alpha, the actin capping protein [3].
  • Meropenem, a new parenteral carbapenem, was tested in vitro by an agar-dilution method against 373 standard strains (aerobes and anaerobes) and against nine expanded-spectrum beta-lactamase-producing strains and their transconjugants (5 CTX-1, 2 CAZ-1, 2 CAZ-2) [4].
  • Against CTX-1-producing strains resistant to cefotaxime and ceftazidime and against CAZ-1 or CAZ-2-producers highly resistant to ceftazidime meropenem was the most active, with MICs lower (0.03-0.12 mg/l) than those of imipenem (0.06-0.5 mg/l), for wild type producers and their transconjugants [4].

Associations of CAPZA1 with chemical compounds

  • The second plasmid-mediated beta-lactamase (CAZ-1) was isolated in 1987 from three K. pneumoniae strains more resistant to ceftazidime than to other third-generation cephalosporins [5].

Other interactions of CAPZA1

  • No new beta-lactamases (SHV-2, CTX-1, TEM-4, CAZ-1) were found in these strains capable of hydrolysing third generation cephalosporins [6].


  1. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. Hutchings, N.J., Clarkson, N., Chalkley, R., Barclay, A.N., Brown, M.H. J. Biol. Chem. (2003) [Pubmed]
  2. Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization. Osterloh, D., Ivanenkov, V.V., Gerke, V. Cell Calcium (1998) [Pubmed]
  3. Identification of the binding site on S100B protein for the actin capping protein CapZ. Kilby, P.M., Van Eldik, L.J., Roberts, G.C. Protein Sci. (1997) [Pubmed]
  4. Comparative in-vitro activity of meropenem against clinical isolates including Enterobacteriaceae with expanded-spectrum beta-lactamases. Chanal, C., Sirot, D., Chanal, M., Cluzel, M., Sirot, J., Cluzel, R. J. Antimicrob. Chemother. (1989) [Pubmed]
  5. Klebsiella pneumoniae and other Enterobacteriaceae producing novel plasmid-mediated beta-lactamases markedly active against third-generation cephalosporins: epidemiologic studies. Sirot, J., Chanal, C., Petit, A., Sirot, D., Labia, R., Gerbaud, G. Rev. Infect. Dis. (1988) [Pubmed]
  6. Comparative activity of cefotetan against plasmid-encoded aminoglycoside-resistant enterobacteria strains. Gomez-Lus, R., Otal, I., Gomez-Lus, M.L., Sarraseca, C., Castillo, J., Gil, J., Rubio, M.C. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1988) [Pubmed]
WikiGenes - Universities