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Gene Review

ROT3  -  3-epi-6-deoxocathasterone 23-monooxygenase

Arabidopsis thaliana

Synonyms: AP22.10, AP22_10, CYP90C1, ROTUNDIFOLIA 3
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High impact information on ROT3


Associations of ROT3 with chemical compounds

  • Our results imply that the ROT3 protein is a member of a new class of cytochrome P-450 encoding putative steroid hydroxylases, which is required for the regulated polar elongation of cells in leaves of Arabidopsis [1].
  • ROT3 appears to be required for the conversion of typhasterol to castasterone, an activation step in the BR pathway [4].

Other interactions of ROT3

  • ROT3 and CYP90D1 were expressed differentially in leaves of A. thaliana, and the mutants for these two genes differed in their defects in elongation of hypocotyls under light conditions [4].
  • We propose that leaf expansion in Arabidopsis involves at least two independent developmental processes: width development and length development, with the ANGUSTIFOLIA and ROTUNDIFOLIA3 genes playing different polarity-specific roles in cell elongation [3].


  1. The ROTUNDIFOLIA3 gene of Arabidopsis thaliana encodes a new member of the cytochrome P-450 family that is required for the regulated polar elongation of leaf cells. Kim, G.T., Tsukaya, H., Uchimiya, H. Genes Dev. (1998) [Pubmed]
  2. C-23 Hydroxylation by Arabidopsis CYP90C1 and CYP90D1 Reveals a Novel Shortcut in Brassinosteroid Biosynthesis. Ohnishi, T., Szatmari, A.M., Watanabe, B., Fujita, S., Bancos, S., Koncz, C., Lafos, M., Shibata, K., Yokota, T., Sakata, K., Szekeres, M., Mizutani, M. Plant Cell (2006) [Pubmed]
  3. Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Tsuge, T., Tsukaya, H., Uchimiya, H. Development (1996) [Pubmed]
  4. CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana. Kim, G.T., Fujioka, S., Kozuka, T., Tax, F.E., Takatsuto, S., Yoshida, S., Tsukaya, H. Plant J. (2005) [Pubmed]
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