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Gene Review

AN  -  C-terminal binding protein AN

Arabidopsis thaliana

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High impact information on AN


Biological context of AN

  • The as1 mutation affected leaf morphology independently of mutations in other genes known to affect leaf morphogenesis, such as the acaulis1 mutation and the angustifolia mutation [6].

Anatomical context of AN

  • De Lanerolle and Cole discuss new insights from plants that show that a plant member of the COOH-terminal binding protein (CtBP) and the brefeldin A adenosine diphosphate (ADP)-ribosylated subtrates (BARS) proteins, ANGUSTIFOLIA, may be a regulator of both the microtubule-based cytoskeleton and a transcriptional regulator [7].

Other interactions of AN

  • We propose that leaf expansion in Arabidopsis involves at least two independent developmental processes: width development and length development, with the ANGUSTIFOLIA and ROTUNDIFOLIA3 genes playing different polarity-specific roles in cell elongation [3].


  1. The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation. Kim, G.T., Shoda, K., Tsuge, T., Cho, K.H., Uchimiya, H., Yokoyama, R., Nishitani, K., Tsukaya, H. EMBO J. (2002) [Pubmed]
  2. DRL1, a homolog of the yeast TOT4/KTI12 protein, has a function in meristem activity and organ growth in plants. Nelissen, H., Clarke, J.H., De Block, M., De Block, S., Vanderhaeghen, R., Zielinski, R.E., Dyer, T., Lust, S., Inzé, D., Van Lijsebettens, M. Plant Cell (2003) [Pubmed]
  3. Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Tsuge, T., Tsukaya, H., Uchimiya, H. Development (1996) [Pubmed]
  4. Characterization of a member of the AN subfamily, IAN, from Ipomoea nil. Cho, K.H., Shindo, T., Kim, G.T., Nitasaka, E., Tsukaya, H. Plant Cell Physiol. (2005) [Pubmed]
  5. The leaf index: heteroblasty, natural variation, and the genetic control of polar processes of leaf expansion. Tsukaya, H. Plant Cell Physiol. (2002) [Pubmed]
  6. Genetic analyses of the formation of the serrated margin of leaf blades in Arabidopsis: combination of a mutational analysis of leaf morphogenesis with the characterization of a specific marker gene expressed in hydathodes and stipules. Tsukaya, H., Uchimiya, H. Mol. Gen. Genet. (1997) [Pubmed]
  7. Cytoskeletal proteins and gene regulation: form, function, and signal transduction in the nucleus. de Lanerolle, P., Cole, A.B. Sci. STKE (2002) [Pubmed]
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