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Gene Review:

HSC70-1 - heat shock cognate protein 70-1

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA HEAT SHOCK COGNATE PROTEIN 70-1, AT-HSC70-1, AtHsp70-1, HEAT SHOCK COGNATE PROTEIN 70, HEAT SHOCK PROTEIN 70-1, ...

Zhang, C. et al., Kim, B.H. et al., Lin, B.L. et al., Lam, B.C. et al., Sung, D.Y. et al., et al.

Ishikawa, Morimoto, Madhusudhan, Sawa, Shibata, Yabuta, Nishizawa, Shigeoka,

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High impact information on HSC70-1

The auxilin-like protein stimulated the uncoating of clathrin-coated vesicles by Hsc70, a reaction that appeared to be inhibited in the presence of AtSH3P1 [1].
The elevated basal levels of HSC70-1 in transgenic plants led to delayed heat shock response of several heat shock genes [2].
HSP70, DnaJ-like protein and purple acid phosphatase were among the constitutively induced genes [3].
Subdomain mapping indicates an interaction of the activation domain and DNA-binding domain of HSF1 with HSP70 [4].
The Arabidopsis genome contains at least 18 genes encoding members of the 70-kilodalton heat shock protein (Hsp70) family, 14 in the DnaK subfamily and 4 in the Hsp110/SSE subfamily [5].

Anatomical context of HSC70-1

Based on these observations, it is concluded that Hsc70 and Hsp101 are present in a complex in the plant cytosol [6].

Analytical, diagnostic and therapeutic context of HSC70-1

Here the interaction between HSF and HSP70 is reported using electrophoretic mobility shift and yeast two-hybrid assays [4].
Co-immunoprecipitation of Hsp101 with cytosolic Hsc70 [6].

References

Role of SH3 domain-containing proteins in clathrin-mediated vesicle trafficking in Arabidopsis. Lam, B.C., Sage, T.L., Bianchi, F., Blumwald, E. Plant Cell (2001) [Pubmed]
Physiological and molecular assessment of altered expression of Hsc70-1 in Arabidopsis. Evidence for pleiotropic consequences. Sung, D.Y., Guy, C.L. Plant Physiol. (2003) [Pubmed]
Acclimation to diverse environmental stresses caused by a suppression of cytosolic ascorbate peroxidase in tobacco BY-2 cells. Ishikawa, T., Morimoto, Y., Madhusudhan, R., Sawa, Y., Shibata, H., Yabuta, Y., Nishizawa, A., Shigeoka, S. Plant Cell Physiol. (2005) [Pubmed]
Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins. Kim, B.H., Schöffl, F. J. Exp. Bot. (2002) [Pubmed]
Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana. Lin, B.L., Wang, J.S., Liu, H.C., Chen, R.W., Meyer, Y., Barakat, A., Delseny, M. Cell Stress Chaperones (2001) [Pubmed]
Co-immunoprecipitation of Hsp101 with cytosolic Hsc70. Zhang, C., Guy, C.L. Plant Physiol. Biochem. (2005) [Pubmed]

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AgaP_AGAP002076	Anopheles gambiae str. PEST
LOC607182	Canis lupus familiaris
si:dkey-4p15.3	Danio rerio
Hsc70-4	Drosophila melanogaster
LOC680121	Rattus norvegicus
LOC100488052	Xenopus (Silurana) tropicalis

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