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Gene Review

PRDX4  -  peroxiredoxin 4

Homo sapiens

Synonyms: AOE37-2, AOE372, Antioxidant enzyme AOE372, HEL-S-97n, PRX-4, ...
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Disease relevance of PRDX4


High impact information on PRDX4

  • Prx I was highly or moderately expressed in 25/36 cases, the corresponding figures for Prxs II-VI being 27/36 (Prx II), 13/36 (Prx III), 2/36 (Prx IV), 24/36 (Prx V), and 30/36 (Prx VI) [3].
  • We cloned a novel AML1 partner gene, PRDX4, in an X;21 translocation in a 74-year-old male patient diagnosed with acute myeloid leukemia-M2 [4].
  • PRDX4 is one of six peroxiredoxin-family genes that are highly conserved in eukaryotes and prokaryotes and are ubiquitously expressed [4].
  • PRDX4 plays a regulatory role in the activation of the transcription factor NF-kappaB and is significantly down-regulated in acute promyelocytic leukemia [4].
  • Other proteins upregulated in spheroids include calreticulin precursor, a rho GDP dissociation inhibitor variant, several cytokeratins and peroxiredoxin 4 [5].

Biological context of PRDX4


Anatomical context of PRDX4

  • Since Prx-IV is involved in the removal of H2O2 in thyroid cells, we hypothesize that mutations in Prx-IV gene are involved in pathogenesis of MNG [7].
  • However, we could not detect Prx-IV in the conditioned media of NIH-3T3 and Jurkat cells [8].

Other interactions of PRDX4

  • CONCLUSIONS: Based on sequence and genomic analysis, Prx-IV is very unlikely to be the MNG2 gene [7].

Analytical, diagnostic and therapeutic context of PRDX4


  1. Peroxiredoxins, a novel protein family in lung cancer. Lehtonen, S.T., Svensk, A.M., Soini, Y., Pääkkö, P., Hirvikoski, P., Kang, S.W., Säily, M., Kinnula, V.L. Int. J. Cancer (2004) [Pubmed]
  2. Biomarker discovery: A proteomic approach for brain cancer profiling. Khalil, A.A., James, P. Cancer Sci. (2007) [Pubmed]
  3. Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. Kinnula, V.L., Lehtonen, S., Sormunen, R., Kaarteenaho-Wiik, R., Kang, S.W., Rhee, S.G., Soini, Y. J. Pathol. (2002) [Pubmed]
  4. PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22). Zhang, Y., Emmanuel, N., Kamboj, G., Chen, J., Shurafa, M., Van Dyke, D.L., Wiktor, A., Rowley, J.D. Genes Chromosomes Cancer (2004) [Pubmed]
  5. Comparison of protein expression profiles between monolayer and spheroid cell culture of HT-29 cells revealed fragmentation of CK18 in three-dimensional cell culture. Poland, J., Sinha, P., Siegert, A., Schnölzer, M., Korf, U., Hauptmann, S. Electrophoresis (2002) [Pubmed]
  6. Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats. Sasagawa, I., Matsuki, S., Suzuki, Y., Iuchi, Y., Tohya, K., Kimura, M., Nakada, T., Fujii, J. Eur. J. Biochem. (2001) [Pubmed]
  7. Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre. Giardina, E., Capon, F., D'Apice, M.R., Amati, F., Arturi, F., Filetti, S., Bonifazi, E., Pucci, S., Conte, C., Novelli, G. BMC Med. Genet. (2002) [Pubmed]
  8. Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species. Wong, C.M., Chun, A.C., Kok, K.H., Zhou, Y., Fung, P.C., Kung, H.F., Jeang, K.T., Jin, D.Y. Antioxid. Redox Signal. (2000) [Pubmed]
  9. Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases. Karasawa, R., Ozaki, S., Nishioka, K., Kato, T. Microbiol. Immunol. (2005) [Pubmed]
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