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Gene Review

Mov10l1  -  Moloney leukemia virus 10-like 1

Mus musculus

Synonyms: CHAMP, Cardiac helicase activated by MEF2 protein, Cardiac-specific RNA helicase, Champ, Csm, ...
 
 
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Disease relevance of Mov10l1

 

High impact information on Mov10l1

 

Biological context of Mov10l1

  • During mouse embryogenesis, CHAMP expression commences in the linear heart tube at embryonic day 8.0, shortly after initiation of MEF2C expression in the cardiogenic region [3].
  • Here, we describe a novel MEF2C-dependent gene that encodes a cardiac-restricted protein, called CHAMP (cardiac helicase activated by MEF2 protein), that contains seven conserved motifs characteristic of helicases involved in RNA processing, DNA replication, and transcription [3].
 

Anatomical context of Mov10l1

  • Csm is expressed specifically in the heart, and its expression in the heart is restricted to cardiac myocytes [2].
 

Other interactions of Mov10l1

  • Csm and HOP were down-regulated in heart failure, and Nkx2-5+/- hearts expressed about half-normal levels in healthy and failing states [4].

References

  1. Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase. Liu, Z.P., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart. Ueyama, T., Kasahara, H., Ishiwata, T., Yamasaki, N., Izumo, S. J. Biol. Chem. (2003) [Pubmed]
  3. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Liu, Z.P., Nakagawa, O., Nakagawa, M., Yanagisawa, H., Passier, R., Richardson, J.A., Srivastava, D., Olson, E.N. Dev. Biol. (2001) [Pubmed]
  4. Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes. Jay, P.Y., Rozhitskaya, O., Tarnavski, O., Sherwood, M.C., Dorfman, A.L., Lu, Y., Ueyama, T., Izumo, S. FASEB J. (2005) [Pubmed]
 
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