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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FIB1  -  probable mediator of RNA polymerase II...

Arabidopsis thaliana

Synonyms: ATFBR1, ATFIB1, FBR1, FIBRILLARIN 1, K24M7.22, ...
 
 
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High impact information on FIB1

  • Identified targets possibly linked to MYC's effects on cell growth include the nucleolar proteins nucleolin and fibrillarin, as well as the eukaryotic initiation factor 5A [1].
  • Our data reveal that the three modes of expression of snoRNAs, single, polycistronic, and intronic, exist in plants and suggest that the mechanisms directing rRNA methylation, dependent on fibrillarin and box C/D snoRNAs, are evolutionarily conserved in plants [2].
  • Interestingly after gene duplication the host intronic sequences completely diverged, but the snoRNA was conserved, even in other crucifer fibrillarin genes [2].
 

Analytical, diagnostic and therapeutic context of FIB1

References

  1. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Coller, H.A., Grandori, C., Tamayo, P., Colbert, T., Lander, E.S., Eisenman, R.N., Golub, T.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Fibrillarin genes encode both a conserved nucleolar protein and a novel small nucleolar RNA involved in ribosomal RNA methylation in Arabidopsis thaliana. Barneche, F., Steinmetz, F., Echeverría, M. J. Biol. Chem. (2000) [Pubmed]
  3. Molecular cloning and targeting of a fibrillarin homolog from Arabidopsis. Pih, K.T., Yi, M.J., Liang, Y.S., Shin, B.J., Cho, M.J., Hwang, I., Son, D. Plant Physiol. (2000) [Pubmed]
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