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Gene Review:

Tex14 - testis expressed gene 14

Mus musculus

Synonyms: C85585, Inactive serine/threonine-protein kinase TEX14, Testis-expressed sequence 14, Testis-expressed sequence 14 protein

Wu, M.H. et al., Greenbaum, M.P. et al.

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High impact information on Tex14

Spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division [1].
Herein, we show that testis-expressed gene 14 (TEX14) is a novel protein that localizes to germ cell intercellular bridges [1].
Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis [2].
Northern blot analysis and in situ hybridization show that Tex14 mRNA is expressed specifically in the testis, with highest levels observed in pachytene, diplotene, and meiotically dividing spermatocytes [2].

References

TEX14 is essential for intercellular bridges and fertility in male mice. Greenbaum, M.P., Yan, W., Wu, M.H., Lin, Y.N., Agno, J.E., Sharma, M., Braun, R.E., Rajkovic, A., Matzuk, M.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. Wu, M.H., Rajkovic, A., Burns, K.H., Yan, W., Lin, Y.N., Matzuk, M.M. Gene Expr. Patterns (2003) [Pubmed]

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