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Gene Review

Tex1  -  testis expressed gene 1

Mus musculus

 
 
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Disease relevance of Tex1

  • The candidacy for infertility of 14 testis-expressed transcripts (TETs) were examined by comparing their chromosomal mapping position to the position of balanced reciprocal translocation breakpoints found in the 265 infertile males [1].
 

High impact information on Tex1

 

Biological context of Tex1

 

Anatomical context of Tex1

  • The spermatic epithelium of the testis expressed the protein moderately [10].
  • Northern blot analysis showed that brown adipose tissue predominantly expressed a 6.5-kb mRNA with lower expression of 4.5- and 2.4-kb forms, whereas brain and pancreatic islets almost exclusively expressed a 6.5-kb transcript, muscle expressed a 4.5-kb transcript, and testis expressed a 2.4-kb RNA form [11].
  • Finally, IDO is not secreted into the epididymal lumen, whereas the testis-expressed TDO is present on the head of spermatozoa retrieved from the cauda epididymidis [12].
  • The testis specificity of the 14 TETs was further examined by reverse transcription-polymerase chain reaction (RT-PCR) on adult and fetal tissues showing that four TETs (TET1 to TET4) were testis-expressed only, six TETs (TET5 to TET10) appeared to be differentially expressed and the remaining four TETs (TET11 to TET14) were ubiquitously expressed [1].
 

Associations of Tex1 with chemical compounds

 

Other interactions of Tex1

  • To identify the causative gene, we have searched YAC clones encompassing the Hst1 region for testis-expressed sequences, using the cDNA selection method [14].
  • This paper presents data on the cellular localization of the testis-expressed mouse Cyrn gene product, cyritestin [15].
  • Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice [16].
  • We have now identified this protein as the testis-expressed 70-kDa heat shock protein chaperone known as HspA2 (the human homologue of mouse Hsp70-2) [17].
  • Testis-expressed genes have been cloned which map to the same subregions of the t-complex as the Tcds and Tcr and are thus considered candidate genes for the products of these loci [18].
 

Analytical, diagnostic and therapeutic context of Tex1

References

  1. Identification of human candidate genes for male infertility by digital differential display. Olesen, C., Hansen, C., Bendsen, E., Byskov, A.G., Schwinger, E., Lopez-Pajares, I., Jensen, P.K., Kristoffersson, U., Schubert, R., Van Assche, E., Wahlstroem, J., Lespinasse, J., Tommerup, N. Mol. Hum. Reprod. (2001) [Pubmed]
  2. A role for the disintegrin domain of cyritestin, a sperm surface protein belonging to the ADAM family, in mouse sperm-egg plasma membrane adhesion and fusion. Yuan, R., Primakoff, P., Myles, D.G. J. Cell Biol. (1997) [Pubmed]
  3. TEX14 is essential for intercellular bridges and fertility in male mice. Greenbaum, M.P., Yan, W., Wu, M.H., Lin, Y.N., Agno, J.E., Sharma, M., Braun, R.E., Rajkovic, A., Matzuk, M.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Differentiation: the selective potentiation of chromatin domains. Kramer, J.A., McCarrey, J.R., Djakiew, D., Krawetz, S.A. Development (1998) [Pubmed]
  5. Expression of the Fas ligand in cells of T cell lineage. Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K., Nagata, S. J. Immunol. (1995) [Pubmed]
  6. The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini. Samant, S.A., Ogunkua, O., Hui, L., Fossella, J., Pilder, S.H. Dev. Biol. (2002) [Pubmed]
  7. Rapid evolution of mammalian X-linked testis-expressed homeobox genes. Wang, X., Zhang, J. Genetics (2004) [Pubmed]
  8. Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation. Obermann, H., Raabe, I., Balvers, M., Brunswig, B., Schulze, W., Kirchhoff, C. Mol. Hum. Reprod. (2005) [Pubmed]
  9. Novel gene acquisition on carnivore Y chromosomes. Murphy, W.J., Wilkerson, A.J., Raudsepp, T., Agarwala, R., Schäffer, A.A., Stanyon, R., Chowdhary, B.P. PLoS Genet. (2006) [Pubmed]
  10. Human kallikrein 10 expression in normal tissues by immunohistochemistry. Petraki, C.D., Karavana, V.N., Luo, L.Y., Diamandis, E.P. J. Histochem. Cytochem. (2002) [Pubmed]
  11. Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase. Koza, R.A., Kozak, U.C., Brown, L.J., Leiter, E.H., MacDonald, M.J., Kozak, L.P. Arch. Biochem. Biophys. (1996) [Pubmed]
  12. Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis. Britan, A., Maffre, V., Tone, S., Drevet, J.R. Cell Tissue Res. (2006) [Pubmed]
  13. Reproductive and genomic effects in testes from mice exposed to the water disinfectant byproduct bromochloroacetic acid. Tully, D.B., Luft, J.C., Rockett, J.C., Ren, H., Schmid, J.E., Wood, C.R., Dix, D.J. Reprod. Toxicol. (2005) [Pubmed]
  14. Isolation of candidate hybrid sterility 1 genes by cDNA selection in a 1.1 megabase pair region on mouse chromosome 17. Trachtulec, Z., Mnuková-Fajdelová, M., Hamvas, R.M., Gregorová, S., Mayer, W.E., Lehrach, H.R., Vincek, V., Forejt, J., Klein, J. Mamm. Genome (1997) [Pubmed]
  15. Delayed translation and posttranslational processing of cyritestin, an integral transmembrane protein of the mouse acrosome. Linder, B., Bammer, S., Heinlein, U.A. Exp. Cell Res. (1995) [Pubmed]
  16. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Ha, H., Howard, C.A., Yeom, Y.I., Abe, K., Uehara, H., Artzt, K., Bennett, D. Dev. Genet. (1991) [Pubmed]
  17. Putative creatine kinase M-isoform in human sperm is identifiedas the 70-kilodalton heat shock protein HspA2. Huszar, G., Stone, K., Dix, D., Vigue, L. Biol. Reprod. (2000) [Pubmed]
  18. Expression of three t-complex genes, Tcp-1, D17Leh117c3, and D17Leh66, in purified murine spermatogenic cell populations. Willison, K.R., Hynes, G., Davies, P., Goldsborough, A., Lewis, V.A. Genet. Res. (1990) [Pubmed]
  19. Molecular and functional analysis of mouse decay accelerating factor (CD55). Harris, C.L., Rushmere, N.K., Morgan, B.P. Biochem. J. (1999) [Pubmed]
 
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