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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TBC1D10A  -  TBC1 domain family, member 10A

Homo sapiens

Synonyms: AC004997.C22.2, EBP50-PDX interactor of 64 kDa, EPI64, EPI64 protein, Rab27A-GAP-alpha, ...
 
 
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High impact information on TBC1D10A

  • High-resolution light microscopy revealed that ezrin and EBP50 localize exclusively to the membrane-surrounded region of microvilli, whereas EPI64 localizes to variable regions in the structures [1].
  • EPI64 is a TBC domain-containing protein that binds the PDZ domains of EBP50, which binds ezrin, a major actin-binding protein of microvilli [1].
  • These data reveal that microvilli have distinct cytoskeletal subdomains and that EPI64 regulates microvillar structure [1].
  • The gene for human EPI64 lies on chromosome 22 where nine exons specify a protein of 508 residues that contains a Tre/Bub2/Cdc16 (TBC)/rab GTPase-activating protein (GAP) domain [2].
  • We further showed that mutations in the catalytic domain of EPI64 caused complete loss of its ability to induce melanosome aggregation [3].
 

Anatomical context of TBC1D10A

 

Other interactions of TBC1D10A

References

  1. EPI64 regulates microvillar subdomains and structure. Hanono, A., Garbett, D., Reczek, D., Chambers, D.N., Bretscher, A. J. Cell Biol. (2006) [Pubmed]
  2. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. Reczek, D., Bretscher, A. J. Cell Biol. (2001) [Pubmed]
  3. Identification of EPI64 as a GTPase-activating Protein Specific for Rab27A. Itoh, T., Fukuda, M. J. Biol. Chem. (2006) [Pubmed]
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