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Gene Review:

VTI1B - vesicle transport v-SNARE 12

Arabidopsis thaliana

Synonyms: ATVTI12, T24P13.5, T24P13_5, VESICAL TRANSPORT V-SNARE 12, VTI12

Surpin, M. et al., Zheng, H. et al., Lee, G.J. et al., Niihama, M. et al., Chen, Y. et al., et al.

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High impact information on VTI12

The Arabidopsis genome contains a family of v-SNAREs: VTI11, VTI12, and VTI13 [1].
An Arabidopsis T-DNA insertion mutant, vti12, had a normal phenotype under nutrient-rich growth conditions [1].
One amino acid substitution drastically altered VTI12, allowing it to suppress abnormalities of higher order physiological functions such as gravitropism and morphology [2].
SYP51 and SYP61 interact with each other and with VTI12, most likely also on the TGN [3].
We propose that AtVTI1a functions as a v-SNARE responsible for targeting AtELP-containing vesicles from the trans-Golgi network to the PVC, and that AtVTI1b is involved in a different membrane transport process [4].

Anatomical context of VTI12

The SNAREs SYP41, SYP61 and VTI12 reside in the trans-Golgi network and have been proposed to function together in vesicle fusion with this organelle [5].

Co-localisations of VTI12

Localization experiments revealed that hemagglutinin epitope-tagged EpsinR2 colocalizes primarily with delta-adaptin and partially colocalizes with clathrin and AtVTI12 [6].

Other interactions of VTI12

Only VTI11 and VTI12 are expressed at appreciable levels [1].

References

The VTI family of SNARE proteins is necessary for plant viability and mediates different protein transport pathways. Surpin, M., Zheng, H., Morita, M.T., Saito, C., Avila, E., Blakeslee, J.J., Bandyopadhyay, A., Kovaleva, V., Carter, D., Murphy, A., Tasaka, M., Raikhel, N. Plant Cell (2003) [Pubmed]
Conversion of functional specificity in Qb-SNARE VTI1 homologues of Arabidopsis. Niihama, M., Uemura, T., Saito, C., Nakano, A., Sato, M.H., Tasaka, M., Morita, M.T. Curr. Biol. (2005) [Pubmed]
Interactions between syntaxins identify at least five SNARE complexes within the Golgi/prevacuolar system of the Arabidopsis cell. Sanderfoot, A.A., Kovaleva, V., Bassham, D.C., Raikhel, N.V. Mol. Biol. Cell (2001) [Pubmed]
The plant vesicle-associated SNARE AtVTI1a likely mediates vesicle transport from the trans-Golgi network to the prevacuolar compartment. Zheng, H., von Mollard, G.F., Kovaleva, V., Stevens, T.H., Raikhel, N.V. Mol. Biol. Cell (1999) [Pubmed]
YKT6 is a core constituent of membrane fusion machineries at the Arabidopsis trans-Golgi network. Chen, Y., Shin, Y.K., Bassham, D.C. J. Mol. Biol. (2005) [Pubmed]
EpsinR2 interacts with clathrin, adaptor protein-3, AtVTI12, and phosphatidylinositol-3-phosphate. Implications for EpsinR2 function in protein trafficking in plant cells. Lee, G.J., Kim, H., Kang, H., Jang, M., Lee, D.W., Lee, S., Hwang, I. Plant Physiol. (2007) [Pubmed]

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