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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADK1  -  dual specificity kinase 1

Arabidopsis thaliana

Synonyms: CASEIN KINASE I-LIKE 9 ALPHA, CASEIN KINASE I-LIKE 9 BETA, CKL9ALPHA, CKL9BETA, DUAL SPECIFICITY KINASE 1, ...
 
 
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High impact information on ADK1

  • Using poly (Glu/Tyr) as a substrate, we confirm that ADK1 is capable of phosphorylating tyrosine residues [1].
  • These results indicate that Ado must be steadily removed by ADK to prevent feedback inhibition of SAH hydrolase and maintain SAM utilization and recycling [2].
  • Adenosine (Ado) kinase (ADK; ATP:Ado 5' phosphotransferase, EC 2.7.1.20) catalyzes the salvage synthesis of adenine monophosphate from Ado and ATP [2].
  • There is a direct correlation between ADK activity and the level of methylesterified pectin in seed mucilage, as monitored by staining with ruthenium red, immunofluorescence labeling, or direct assay [2].
  • Adenosine kinase (ADK, EC 2.7.1.20) is a purine salvage enzyme, which phosphorylates adenosine (Ado) to AMP [3].
 

Anatomical context of ADK1

  • As such, ADK was found to increase during events associated with high transmethylation activity, such as cell wall synthesis and seed filling [3].

References

  1. Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine. Ali, N., Halfter, U., Chua, N.H. J. Biol. Chem. (1994) [Pubmed]
  2. Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Moffatt, B.A., Stevens, Y.Y., Allen, M.S., Snider, J.D., Pereira, L.A., Todorova, M.I., Summers, P.S., Weretilnyk, E.A., Martin-McCaffrey, L., Wagner, C. Plant Physiol. (2002) [Pubmed]
  3. Applying high throughput techniques in the study of adenosine kinase in plant metabolism and development. Schoor, S., Moffatt, B.A. Front. Biosci. (2004) [Pubmed]
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